Large Intronic Deletion of the Fragile Site Gene PRKN Dramatically Lowers Its Fragility Without Impacting Gene Expression
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DOI: 10.3389/fgene.2021.695172
Abstract: Common chromosomal fragile sites (CFSs) are genomic regions prone to form breaks and gaps on metaphase chromosomes during conditions of replication stress. Moreover, CFSs are hotspots for deletions and amplifications in cancer genomes. Fragility at… read more here.
Keywords: fragility; expression; prkn; intronic deletion ... See more keywords