Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-3233-2_15
Abstract: Acute myeloid leukemia (AML) is characterized by recurrent chromosomal rearrangements that encode for fusion proteins which drive leukemia initiation and maintenance. The inv(16) (p13q22) rearrangement is a founding mutation and the associated CBFβ-SMMHC fusion protein… read more here.
Keywords: cbf smmhc; inv; myeloid leukemia; acute myeloid ... See more keywords
Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma
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DOI: 10.1038/s41416-019-0622-3
Abstract: Background Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). Methods The number of CD8… read more here.
Keywords: surf; different locations; inv; cent ... See more keywords
POS1351 CAUSES OF HOSPITALIZATION IN BEHÇET SYNDROME
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DOI: 10.1136/annrheumdis-2021-eular.1987
Abstract: The causes of hospitalization may provide important information on the course of diseases and treatment-related adverse effects.We aimed to determine the causes and outcome of hospitalizations among patients with Behçet Syndrome (BS) in a dedicated… read more here.
Keywords: causes hospitalization; non related; patients hospitalized; related reasons ... See more keywords
The Motion of An Inv Nodal Cilium: a Realistic Model Revealing Dynein-Driven Ciliary Motion with Microtubule Mislocalization
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DOI: 10.1159/000496038
Abstract: Background/Aims: Nodal cilia that rotate in the ventral node play an important role in establishing left-right asymmetry during embryogenesis; however, inv mutant cilia present abnormal movement and induce laterality defects. The mechanism of their motility,… read more here.
Keywords: microtubule; motion; movement; cilium ... See more keywords
Anti-MiR-126 Therapy for Inv(16) Acute Myeloid Leukemia
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DOI: 10.1182/blood-2019-123468
Abstract: Inv(16)(p13q22) or t(16;16)(p13.1;q22) [hereafter inv(16)], a chromosomal rearrangement occurred in 5-12% acute myeloid leukemia (AML) patients, disrupts the core-binding factor (CBF) transcription complex and creates a leukemogenic fusion gene CBFb-MYH11 (CM). Only about 50% inv(16)… read more here.
Keywords: mir 126; inv; pre; aml ... See more keywords
Molecular and Clinical Aspects of Acute Myeloid Leukemia with Inv(3)(q21q26)/t(3;3)(q21;q26) Carrying Spliceosomal Mutations
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DOI: 10.1182/blood-2020-139953
Abstract: Inversion or translocation of the chromosome 3, specifically inv(3)(q21q26.2/ t(3;3)(q21;q26.2) are present in 1-2% of acute myeloid leukemia (AML) cases and are classified as a distinct entity in the 2016 WHO classification. Hallmark genetic alterations… read more here.
Keywords: sf3b1 mutations; inv; aml inv; inv aml ... See more keywords