Molecular and Clinical Aspects of Acute Myeloid Leukemia with Inv(3)(q21q26)/t(3;3)(q21;q26) Carrying Spliceosomal Mutations
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DOI: 10.1182/blood-2020-139953
Abstract: Inversion or translocation of the chromosome 3, specifically inv(3)(q21q26.2/ t(3;3)(q21;q26.2) are present in 1-2% of acute myeloid leukemia (AML) cases and are classified as a distinct entity in the 2016 WHO classification. Hallmark genetic alterations… read more here.
Keywords: sf3b1 mutations; inv; aml inv; inv aml ... See more keywords
Cohesin Haploinsufficiency Drives Leukemic Initiation through Fli1 Upregulation in Inv(16) AML
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DOI: 10.1182/blood-2024-200326
Abstract: Acute myeloid leukemia (AML) is a genetically diverse cancer of the bone marrow that affects approximately 20,000 new patients annually in the US alone. Many mutations drive leukemogenesis, including those in the core binding factor… read more here.
Keywords: inv smc3; initiation; inv; fli1 ... See more keywords