CD73 facilitates invadopodia formation and boosts malignancy of head and neck squamous cell carcinoma via the MAPK signaling pathway
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DOI: 10.1111/cas.15452
Abstract: Elevated adenosine generated by CD73 (ecto‐5′‐nucleotidase; NT5E) could boost immunosuppressive responses and promote immune evasion in the tumor microenvironment. However, despite the immune response, CD73 could also promote tumor progression in a variety of cancers,… read more here.
Keywords: cd73; cell; signaling pathway; invadopodia formation ... See more keywords
Abstract A08: PI3Kbeta regulates beta-1 integrin signaling in invadopodia through formation of PI(3,4)P2
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DOI: 10.1158/1557-3125.pi3k-mtor18-a08
Abstract: The PI3Kbeta isoform of PI 3-kinase, which is activated downstream from both RTKs and GPCRs, is an important regulator of invadopodia formation. We have previously reported that in MDA-MB-231 breast cancer cells, replacement of endogenous… read more here.
Keywords: pi3kbeta; invadopodia formation; beta integrin; integrin signaling ... See more keywords
Role of Novel Therapeutic Agents in Modulating Invadopodia Formation in Metastatic Breast Cancer
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DOI: 10.17576/jsm-2020-4906-13
Abstract: The ability to colonize distant organs which is lethal has made metastatic breast cancer become the top ten causes of mortality worldwide. Specialized actin-rich protrusions termed invadopodia were thought to be formed by highly invasive… read more here.
Keywords: cancer; metastatic breast; invadopodia formation; breast cancer ... See more keywords
NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma
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DOI: 10.18632/oncotarget.25347
Abstract: Neural precursor cell expressed developmentally downregulated 9 (NEDD9) is a component of the metastatic signatures of melanoma, breast cancer, glioblastoma, lung cancer and head and neck squamous cell carcinoma (HNSCC). Here we tested the efficacy… read more here.
Keywords: secretion; mmp9 secretion; invadopodia formation; cell ... See more keywords
CAIX Regulates Invadopodia Formation through Both a pH-Dependent Mechanism and Interplay with Actin Regulatory Proteins
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DOI: 10.3390/ijms20112745
Abstract: Tumor metastasis is tightly linked with invasive membrane protrusions, invadopodia, formed by actively invading tumor cells. Hypoxia and pH modulation play a role in the invadopodia formation and in their matrix degradation ability. Tumor-associated carbonic… read more here.
Keywords: invadopodia formation; caix; tumor cells;