Lipocalin 2 inhibits actin glutathionylation to promote invasion and migration
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14572
Abstract: Invasive and metastatic tumor cells show an increase in migration and invasion, making the processes contributing to these phenotypes potential therapeutic targets. Lipocalin 2 (LCN2; also known as neutrophil gelatinase‐associated lipocalin) is a putative therapeutic… read more here.
Keywords: invasion migration; inhibits actin; migration; actin glutathionylation ... See more keywords
DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12089
Abstract: Gastric cancer (GC) represents the fourth most common malignant neoplasm and the second leading cause of cancer death. Despite therapeutic advances in recent decades, the clinical outcome remains dismal owing to the fact that most… read more here.
Keywords: ddah1; invasion; gastric cancer; catenin ... See more keywords
Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202008400
Abstract: Hydrogel models of metastasis traditionally focus on the invasion of cancer cells; however, other cells in the tumor microenvironment that are associated with metastasis also have the ability to migrate. Macrophage phenotype plays a key… read more here.
Keywords: macrophage invasion; crosslinked cryogels; macrophage; invasion ... See more keywords
Glioblastoma Spheroid Invasion through Soft, Brain‐Like Matrices Depends on Hyaluronic Acid–CD44 Interactions
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203143
Abstract: Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) patients. GBM cells aggressively invade the brain parenchyma while encountering spatiotemporal changes… read more here.
Keywords: cell; cd44; brain; concentration ... See more keywords
Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202101923
Abstract: Diffuse invasion is the primary cause of treatment failure of glioblastoma (GBM). Previous studies on GBM invasion have long been forced to use the resected tumor mass cells. Here, a strategy to reliably isolate matching… read more here.
Keywords: tumor mass; invasion; spatial dissection; gbmtc cells ... See more keywords
High-Throughput Electromechanical Coupling Chip Systems for Real-Time 3D Invasion/Migration Assay of Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300882
Abstract: Cell invasion/migration through three-dimensional (3D) tissues is not only essential for physiological/pathological processes, but a hallmark of cancer malignancy. However, how to quantify spatiotemporal dynamics of 3D cell migration/invasion is challenging. Here, this work reports… read more here.
Keywords: invasion migration; coupling chip; migration assay; migration ... See more keywords
Cross‐Species Insights into Trophoblast Invasion During Placentation Governed by Immune‐Featured Trophoblast Cells (Adv. Sci. 42/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470256
Abstract: Cross‐Species Insights into Trophoblast Invasion The image depicts the important roles of iTrophoblast in invasive placentation through the Chinese mythology “Hundred Birds Paying Homage to the Phoenix”. During placentation, iTrophoblast (Phoenix) regulates the invasion of… read more here.
Keywords: trophoblast invasion; species insights; insights trophoblast; invasion ... See more keywords
SLPI⁺ AT2-Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202516580
Abstract: The spatial organization of the tumor microenvironment (TME) profoundly influences cancer biology. However, the cell types and spatial distribution driving lung adenocarcinoma (LUAD) invasion remain poorly understood. By integrating spatially resolved transcriptomics with scRNA-seq data,… read more here.
Keywords: like cells; lung adenocarcinoma; slpi at2; tumor ... See more keywords
Three‐dimensional microfluidic tumor–macrophage system for breast cancer cell invasion
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26961
Abstract: The recrudescence of breast cancer can partly be attributed to poor understanding of the early steps and the mechanisms involved in breast cancer metastasis, especially how tumor inflammatory cells including tumor‐associated macrophages (TAM) affect invasion… read more here.
Keywords: system; breast; invasion; breast cancer ... See more keywords
CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial–mesenchymal transition and suppressing apoptosis through AKT pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1039
Abstract: Chemokine and the chemokine receptor have a key role in the tumor progress. Here, we supposed that CCR7 might induce the invasion, migration, and epithelial–mesenchymal transition (EMT) process of breast cancer. In this research, human… read more here.
Keywords: invasion; migration; ccr7; breast cancer ... See more keywords
High expression of DJ‐1 promotes growth and invasion via the PTEN‐AKT pathway and predicts a poor prognosis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1325
Abstract: Cancer cell invasion and unlimited proliferation are key factors in patients with colorectal cancer (CRC). Increased protein deglycase DJ‐1 in cancer cells is known to promote tumor growth; however, its role in CRC progression is… read more here.
Keywords: invasion; colorectal cancer; crc; cancer ... See more keywords