18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61700-6
Abstract: Invasive mold infections are a major cause of mortality in immunosuppressed and cancer patients. Diagnosis is challenging, requiring invasive procedures or reliance on fungal biomarkers with limited sensitivity and an inability to detect non-Aspergillus molds.… read more here.
Keywords: fds pet; invasive mold; mold infections; 18f fluorodeoxysorbitol ... See more keywords
Evolution of antifungals for invasive mold infections in immunocompromised hosts, then and now
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2023.2207821
Abstract: ABSTRACT Introduction The current armamentarium of antifungal agents for invasive mold infections (IMI) has dramatically improved over the last 50 years. Existing therapies are, however, associated with toxicities, drug interactions, and, in some cases, therapeutic failures.… read more here.
Keywords: invasive mold; mold infections; infections immunocompromised; antifungals invasive ... See more keywords
Invasive mold infection of the gastrointestinal tract: A case series of 22 immunocompromised patients from a single academic center
Sign Up to like & getrecommendations! Published in 2022 at "Medical Mycology"
DOI: 10.1093/mmy/myac007
Abstract: Abstract Invasive mold infection (IMI) of the gastrointestinal (GI) tract is a rare complication in immunocompromised patients that carries a high mortality rate. It is most often described in the setting of disseminated disease. Early… read more here.
Keywords: invasive mold; mold infection; infection; immunocompromised patients ... See more keywords
1153. Characterization of Invasive Mold Infections in Acute Leukemia and Hematopoietic Stem Cell Transplant Recipient Patients and Risk Factors for Mortality - a Single Center Experience
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DOI: 10.1093/ofid/ofaa439.1339
Abstract: Invasive mold infections (IMIs) remain a significant cause of morbidity and mortality in patients with acute leukemia (AL) and those undergoing hematopoietic stem cell transplantation (HSCT). We describe the epidemiology of IMIs, the incidence of… read more here.
Keywords: invasive mold; diagnosis; mold infections; mortality ... See more keywords
P-1026. Predictors of Consolidations, Such as Non-Round Image Pattern, in CT Findings in Patients with Invasive Mold Pneumonia
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.1216
Abstract: Abstract Background CT is important to diagnose pulmonary invasive mold infection (PIMI). According to 2008 European Organization for Research and Treatment of Cancer (EORTC) criteria, dense, well-circumscribed lesion(s) was listed, but the recent 2020 EORTC… read more here.
Keywords: 1026 predictors; lesion; eortc criteria; invasive mold ... See more keywords
P-1043. Risk Factors for Breakthrough Invasive Mold Infections in Patients with Hematologic Malignancies
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.1233
Abstract: Abstract Background Invasive mold infections (IMI) lead to significant morbidity and mortality in patients with hematologic malignancies. We provide patients deemed at higher risk mold active prophylaxis but still observe breakthrough IMIs. The purpose of… read more here.
Keywords: breakthrough imis; risk; invasive mold; risk factors ... See more keywords
Breakthrough Invasive Mold Infections in Hematologic Cases: Relevance of the Host's Factors
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DOI: 10.1093/ofid/ofaf025
Abstract: Abstract Background Breakthrough invasive mold infections (bIMIs) are life-threatening complications in hematologic cases. Most previous studies in this field covered the whole spectrum of fungal pathogens, including yeasts, and antifungal agents. Methods We conducted a… read more here.
Keywords: hematologic cases; invasive mold; breakthrough invasive; mold infections ... See more keywords
Isavuconazole for the Treatment of Invasive Mold Disease in Solid Organ Transplant Recipients: A Multicenter Study on Efficacy and Safety in Real-life Clinical Practice
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DOI: 10.1097/tp.0000000000004312
Abstract: Background. Isavuconazole has theoretical advantages over other mold-active triazoles for the treatment of invasive aspergillosis and mucormycosis after solid organ transplantation (SOT). The available clinical experience, nevertheless, is scarce. Methods. We performed a retrospective study… read more here.
Keywords: invasive mold; mold disease; therapy; treatment invasive ... See more keywords
Therapeutic Challenges of Non-Aspergillus Invasive Mold Infections in Immunosuppressed Patients
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DOI: 10.1128/aac.01244-19
Abstract: While Aspergillus spp. remain the major cause of invasive mold infections in hematologic cancer patients and transplant recipients, other opportunistic molds, such as Mucorales, Fusarium, and Scedosporium spp. are increasingly encountered in an expanding population… read more here.
Keywords: invasive mold; spp; non aspergillus; mold infections ... See more keywords
Ibrexafungerp, a Novel Triterpenoid Antifungal in Development for the Treatment of Mold Infections
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8111121
Abstract: Molds are ubiquitous in the environment, and immunocompromised patients are at substantial risk of morbidity and mortality due to their underlying disease and the resistance of pathogenic molds to currently recommended antifungal therapies. This combination… read more here.
Keywords: invasive mold; mold infections; ibrexafungerp novel; fungal infections ... See more keywords