Adjuvant immunotherapy for muscle-invasive urothelial carcinoma of the bladder
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2038565
Abstract: ABSTRACT Introduction There are substantial unmet needs with regards to adjuvant therapy for muscle-invasive urothelial carcinoma (UC) of the bladder, including patients with persistent disease histologically following neoadjuvant platinum-based therapy and radical resection, as well… read more here.
Keywords: carcinoma bladder; immunotherapy; invasive urothelial; urothelial carcinoma ... See more keywords
Adjuvant treatment following radical cystectomy for muscle-invasive urothelial carcinoma and variant histologies: Is there a role for radiotherapy?
Sign Up to like & getrecommendations! Published in 2017 at "ESMO Open"
DOI: 10.1136/esmoopen-2016-000123
Abstract: Comprehensive molecular characterisation of muscle-invasive urothelial carcinoma and variant histological subtypes has led to the identification of recurrent driver mutations that are distinct in these aggressive subgroups of bladder cancer. While distant metastasis dominates as… read more here.
Keywords: invasive urothelial; treatment; radiotherapy; muscle invasive ... See more keywords
Integrative analysis of the epigenetic basis of muscle-invasive urothelial carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Epigenetics"
DOI: 10.1186/s13148-018-0451-x
Abstract: BackgroundElucidation of epigenetic alterations in bladder cancer will lead to further understanding of the biology of the disease and hopefully improved therapies. Our aim was to perform an integrative epigenetic analysis of invasive urothelial carcinoma… read more here.
Keywords: genes involved; invasive urothelial; analysis; urothelial carcinoma ... See more keywords
The neural phenotype in invasive urothelial carcinoma patients: Alternative score detection and prognostic implication.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e17037
Abstract: e17037Background: Recent molecular subtyping studies (NGS) identified a subset (5-15%) of muscle invasive urothelial carcinoma (MIBC) with transcriptomic patterns consistent with neuroendocrine (NE... read more here.
Keywords: neural phenotype; invasive urothelial; urothelial carcinoma; carcinoma patients ... See more keywords
PROOF 302: A randomized, double-blind, placebo-controlled, phase III trial of infigratinib as adjuvant therapy in patients with invasive urothelial carcinoma harboring susceptible FGFR3 alterations.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.tps5095
Abstract: TPS5095Background: Radical surgery ± cisplatin‐based (neo)adjuvant chemotherapy (NAC) is the mainstay of treatment for invasive urothelial carcinoma of the upper urinary tract (UTUC) or bladder (UB... read more here.
Keywords: randomized double; proof 302; 302 randomized; urothelial carcinoma ... See more keywords
Adding mitomycin to Bacillus Calmette-Guérin as adjuvant intravesical therapy for high-risk, nonmuscle-invasive urothelial bladder cancer (BCGMM; ANZUP 1301).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.tps602
Abstract: TPS602Background: Adjuvant intravesical bacillus Calmette-Guerin (BCG) decreases disease recurrence and progression in people with high-risk, non-muscle invasive urothelial bladder cancer (NMIBC), ... read more here.
Keywords: bladder cancer; invasive urothelial; urothelial bladder; high risk ... See more keywords
Bladder preservation in complicated invasive urothelial carcinoma following treatment with cisplatin/gemcitabine plus tislelizumab: A case report
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v11.i5.1165
Abstract: BACKGROUND Invasive urothelial carcinoma (UC) with squamous and glandular differentiation is a highly malignant and complicated pathological subtype, and the standard care is radical cystectomy (RC). However, urinary diversion after RC significantly reduces patient quality… read more here.
Keywords: cisplatin gemcitabine; bladder; invasive urothelial; case ... See more keywords
Pelvic lymphadenectomy for muscle invasive urothelial carcinoma: extended morbidity for limited benefit?
Sign Up to like & getrecommendations! Published in 2019 at "Translational andrology and urology"
DOI: 10.21037/tau.2018.12.11
Abstract: Lymph node dissection (LND) in muscle invasive urothelial carcinoma in the bladder provides staging and prognostic information to guide further treatment options. It may have a therapeutic role in treating early metastatic disease (1). The… read more here.
Keywords: urothelial carcinoma; pelvic lymphadenectomy; invasive urothelial; muscle invasive ... See more keywords
Treatment of muscle-invasive urothelial cancer with nivolumab (CheckMate 274 study): a plain language summary.
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DOI: 10.2217/fon-2022-1294
Abstract: WHAT IS THIS SUMMARY ABOUT? This is a summary of a paper published in a medical journal that describes the results of a study called CheckMate 274. This study looked at a new treatment for… read more here.
Keywords: cancer; muscle invasive; invasive urothelial; urothelial cancer ... See more keywords
Naturally-Occurring Invasive Urothelial Carcinoma in Dogs, a Unique Model to Drive Advances in Managing Muscle Invasive Bladder Cancer in Humans
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01493
Abstract: There is a great need to improve the outlook for people facing urinary bladder cancer, especially for patients with invasive urothelial carcinoma (InvUC) which is lethal in 50% of cases. Improved outcomes for patients with… read more here.
Keywords: bladder cancer; invasive urothelial; invuc; model ... See more keywords
PD-L1 expression in muscle invasive urothelial carcinoma: Comparison of SP142 and SP263 assay
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Pathology and Microbiology"
DOI: 10.4103/ijpm.ijpm_1472_20
Abstract: Introduction: High-grade urothelial carcinoma has a different molecular pathway than superficial low grade urothelial carcinoma, and is characterized by genomic instability. The high tumor mutation burden leads to neoantigen formation, evoking an immune response. The… read more here.
Keywords: invasive urothelial; sp142; sp263 assay; urothelial carcinoma ... See more keywords