From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac203
Abstract: The exponential accumulation of DNA sequencing data has opened new avenues for discovering the causative roles of single-nucleotide polymorphisms (SNPs) in neurological disease. The opportunities emerging from this are staggering, yet only as good as… read more here.
Keywords: bugs bedside; disease; functional annotation; invertebrate models ... See more keywords
Toxicity of plant extracts containing pyrrolizidine alkaloids using alternative invertebrate models
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8795
Abstract: Pyrrolizidine alkaloids (PAs) are a widespread class of hepatotoxic heterocyclic organic compounds found in approximately 3% of world flora. Some PAs have been shown to have genotoxic and carcinogenic effects. The present study focuses on… read more here.
Keywords: toxicity plant; invertebrate models; extracts containing; toxicity ... See more keywords