Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers
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DOI: 10.1080/14756366.2022.2150762
Abstract: Abstract The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held together via linkers of variable lengths containing a… read more here.
Keywords: tacrine; inhibition; investigation enantioselectivity; enantioselectivity acetylcholinesterase ... See more keywords