Synthesis and investigation of inhibitory activities of imidazole derivatives against the metallo-β-lactamase IMP-1.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103277
Abstract: Mutations in bacteria can result in antibiotic resistance due to the overuse or abuse of β-lactam antibiotics. One strategy which bacteria can become resistance toward antibiotics is secreting of metallo β-lactamase enzymes that can open… read more here.
Keywords: imp; investigation inhibitory; imidazole derivatives; synthesis investigation ... See more keywords
Investigation of the inhibitory effects of isoindoline-1,3-dion derivatives on hCA-I and hCA-II enzyme activities
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.07.070
Abstract: Abstract Inhibition of carbonic anhydrase (CA) has emerged as a promising approach for the treatment of a variety of diseases such as glaucoma, epilepsy, obesity and cancer. As a result, the design of CA inhibitors… read more here.
Keywords: investigation inhibitory; inhibitory effects; isoindoline dion; effects isoindoline ... See more keywords