A Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs.
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DOI: 10.1021/acs.jmedchem.9b01172
Abstract: Optimization of compound lipophilicity is a key aspect of drug discovery. The aim of this work was to compare the lipophilicity modulations induced by 16 distinct known and novel fluoroalkyl motifs on three parent models.… read more here.
Keywords: investigation lipophilicity; lipophilicity; aliphatic fluorination; fluorination motifs ... See more keywords