Investigation of Sequence‐Penetration Relationships of Antisense Oligonucleotides
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DOI: 10.1002/cbic.202300009
Abstract: A major limitation for the development of more effective oligonucleotide therapeutics has been a lack of understanding of their penetration into the cytosol. While prior work has shown how backbone modifications affect cytosolic penetration, it… read more here.
Keywords: investigation sequence; cytosolic penetration; penetration; sequence ... See more keywords
Systematic investigation of sequence requirements for DNA i-motif formation
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DOI: 10.1093/nar/gkz046
Abstract: Abstract The formation of intercalated motifs (iMs) — secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is reflected by typical changes in CD and UV absorption spectra. By means of… read more here.
Keywords: requirements dna; investigation sequence; formation; dna motif ... See more keywords