A summary of the current drug interaction guidance from the European Medicines Agency and considerations of future updates.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.11.005
Abstract: The current EMA drug interaction guideline was published in 2012. This guideline gives important recommendations on the information required to elucidate the interaction potential of an investigational drug, both as effects of the investigational drug… read more here.
Keywords: guideline; drug interaction; investigational drug; summary current ... See more keywords
Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00048
Abstract: An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented and reversed synaptotoxic… read more here.
Keywords: drug ct1812; investigational drug; alzheimer disease; receptor complex ... See more keywords
Participation in ENSEMBLE phase III multicenter clinical trial of Ad26.CoV2.S, a COVID‐19 vaccine: An investigational drug services perspective
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13476
Abstract: Abstract What is known and objective Since WHO declared the pandemic of COVID‐19, vaccines have been developed to fight against this infectious disease. Coordination and participation of investigational drug services to facilitate a phase III… read more here.
Keywords: investigational drug; covid; phase iii;