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Published in 2021 at "Journal of Bioethical Inquiry"
DOI: 10.1007/s11673-021-10090-7
Abstract: Treating physicians have key roles to play in expanded access to investigational drugs, by identifying investigational treatment options, assessing the balance of risks and potential benefits, informing their patients, and applying to the regulatory authorities.…
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Keywords:
mixed methods;
methods study;
investigational drugs;
access investigational ... See more keywords
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Published in 2018 at "Health policy"
DOI: 10.1016/j.healthpol.2018.06.005
Abstract: BACKGROUND Today, public and private bodies around the world are trying to facilitate and increase expanded access to unapproved, investigational drugs for patients with unmet medical needs. METHODS This paper discusses three major shifts in…
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Keywords:
facilitate expanded;
investigational drugs;
efforts facilitate;
ethical issues ... See more keywords
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Published in 2017 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2017.1324571
Abstract: ABSTRACT Introduction: Multiple myeloma (MM) is a hematologic malignancy characterized by proliferation of malignant plasma cells. patient outcome has improved markedly over the last decades due to the introduction of novel therapeutic agents such as…
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Keywords:
multiple myeloma;
investigational drugs;
agent activity;
single agent ... See more keywords
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Published in 2018 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2018.1412430
Abstract: ABSTRACT Introduction: Hidradenitis suppurativa is a chronic skin disease with a significant unmet need for treatment options. Randomized controlled trials are few and only a single drug (adalimumab) has Hidradenitis as a registered indication. Areas…
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Keywords:
investigational drugs;
hidradenitis suppurativa;
clinical trials;
drugs clinical ... See more keywords
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Published in 2018 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2018.1533550
Abstract: ABSTRACT Introduction: Psoriasis is a common immune disorder for which there are many FDA-approved therapies. Older oral drugs had limited efficacy and considerable side effects. Biologics have been a major advance but require self-administered injections,…
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Keywords:
investigational drugs;
oral drugs;
clinical trials;
psoriasis ... See more keywords
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Published in 2018 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2018.1543659
Abstract: ABSTRACT Introduction: Squamous cell carcinoma of the anal canal (SCCA) is a rare malignancy, but its incidence rates have been increasing in the last decade. Studies have demonstrated that up to 47% of patients with…
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Keywords:
treatment anal;
experimental investigational;
investigational drugs;
treatment ... See more keywords
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Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2019.1638364
Abstract: ABSTRACT Introduction: Acute otitis media (AOM) is a common disease, particularly in infants and young children. Almost all children experience at least one episode of AOM in the first 3 years of age, and approximately…
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Keywords:
acute otitis;
investigational drugs;
otitis media;
experimental investigational ... See more keywords
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Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2020.1708324
Abstract: ABSTRACT Introduction: Despite current guideline-based, secondary prevention strategies in patients with the acute coronary syndrome, the residual ischemic risk is still at an unacceptable rate, and there is a concomitant high bleeding event rate. These…
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Keywords:
investigational drugs;
acute coronary;
phase trials;
phase clinical ... See more keywords
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Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2033207
Abstract: ABSTRACT Introduction Current treatments of eosinophilic esophagitis (EoE) induce symptomatic and histological remission in a proportion of patients. However, they do not fully meet patients’ needs and limitations should be acknowledged. The growing epidemiology of…
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Keywords:
investigational drugs;
eosinophilic esophagitis;
current options;
drugs treatment ... See more keywords
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Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2075340
Abstract: ABSTRACT Introduction Primary immune thrombocytopenia (ITP) is an acquired autoimmune disease of unknown cause. Autoantibodies, self-reactive T cells and other immune abnormalities, with impairment of platelet production, lead to a reduced platelet count. Until recently,…
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Keywords:
drugs immune;
receptor;
investigational drugs;
immune thrombocytopenia ... See more keywords
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Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2087059
Abstract: ABSTRACT Introduction Chronic hand eczema (CHE) is a highly prevalent, burdensome condition associated with functional impairment. Currently, topical therapeutics are the mainstay of CHE management. However, many cases are refractory to existing topical therapeutics, and…
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Keywords:
investigational drugs;
emerging investigational;
chronic hand;
che ... See more keywords