Matching within a hybrid RCT/RWD: framework on associated causal estimands.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2022.2105346
Abstract: As the regulatory environment becomes progressively receptive toward utilizing real-world evidence, a spectrum of real-world data incorporation techniques in trial conduct and analysis has seen increasing interest and adoption in different stages of drug development.… read more here.
Keywords: investigational treatment; matching schemes; matching within; control ... See more keywords
A Validation Study of the Rank-Preserving Structural Failure Time Model: Confidence Intervals and Unique, Multiple, and Erroneous Solutions
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DOI: 10.1177/0272989x18765175
Abstract: Background. The rank-preserving structural failure time model (RPSFTM) is used for health technology assessment submissions to adjust for switching patients from reference to investigational treatment in cancer trials. It uses counterfactual survival (survival when only… read more here.
Keywords: preserving structural; structural failure; treatment; time ... See more keywords