A zebrafish model to study small-fiber neuropathy reveals a potential role for GDAP1.
Sign Up to like & getrecommendations! Published in 2019 at "Mitochondrion"
DOI: 10.1016/j.mito.2019.01.002
Abstract: Mutations in genes involved in mitochondrial dynamics (fusion and fission) have been implicated in many peripheral neuropathies. We hypothesized that defects in these genes could result in a phenotype resembling features of small-fiber neuropathy (SFN).… read more here.
Keywords: genes involved; fiber neuropathy; small fiber; involved mitochondrial ... See more keywords
Polymerase ΞΆ Is Involved in Mitochondrial DNA Maintenance Processes in Concert with APE1 Activity
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13050879
Abstract: Mitochondrial DNA (mtDNA) damaged by reactive oxygen species (ROS) triggers so far poorly understood processes of mtDNA maintenance that are coordinated by a complex interplay among DNA repair, DNA degradation, and DNA replication. This study… read more here.
Keywords: dna; maintenance; involved mitochondrial; mitochondrial dna ... See more keywords
Mitochondrial proteomics reveal potential targets involved in mitochondrial abnormalities of desminopathy.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical neuropathology"
DOI: 10.5414/np300969
Abstract: AIMS To investigate the underlying mechanisms of how the defects of desmin cause mitochondrial abnormalities in desminopathy. MATERIAL AND METHODS Primary myoblasts were isolated from muscle biopsy of a desminopathy patient with mitochondrial abnormalities. Two-dimensional… read more here.
Keywords: mitochondrial proteomics; involved mitochondrial; potential targets; targets involved ... See more keywords