Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.01.012
Abstract: Summary Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative resting membrane potential (RMP), which is attributed to small inward rectifier currents (IK1). Here, IK1 was measured in hiPSC-CMs (proprietary and commercial cell… read more here.
Keywords: cms; membrane potential; resting membrane; hipsc cms ... See more keywords
Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918387117
Abstract: Significance Ion channels form pores that allow for the selective transport of ions across cell membranes, generating electrical signals in response to a variety of signals. Inward rectifier potassium (Kir) channels in particular are regulated… read more here.
Keywords: kir2; rectifier potassium; lipid species; membrane ... See more keywords
P1235Acetylcholine-activated inward-rectifier potassium currents in atrial cardiomyocytes derived from induced pluripotent stem cells and atrial engineered heart muscle preparations
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz748.0193
Abstract: Abnormal activity of muscarinic receptor (M-receptor) activated potassium current (IK,ACh) has been suggested as a potential atrial-specific drug target for antiarrhythmic therapy in patients with atrial fibrillation (AF). Recent work suggests that atrial myocytes derived… read more here.
Keywords: heart; cch; induced pluripotent; receptor ... See more keywords
Boosting the signal: Endothelial inward rectifier K+ channels
Sign Up to like & getrecommendations! Published in 2017 at "Microcirculation"
DOI: 10.1111/micc.12319
Abstract: Endothelial cells express a diverse array of ion channels including members of the strong inward rectifier family composed of KIR2 subunits. These two‐membrane spanning domain channels are modulated by their lipid environment, and exist in… read more here.
Keywords: kir; boosting signal; hyperpolarization; signal endothelial ... See more keywords
Inward Rectifier Potassium Channels: Membrane Lipid-Dependent Mechanosensitive Gates in Brain Vascular Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.869481
Abstract: Cerebral arteries contain two primary and interacting cell types, smooth muscle (SMCs) and endothelial cells (ECs), which are each capable of sensing particular hemodynamic forces to set basal tone and brain perfusion. These biomechanical stimuli… read more here.
Keywords: kir2 channels; potassium channels; inward rectifier; rectifier potassium ... See more keywords
Quantitative Analysis of the Cytoskeleton’s Role in Inward Rectifier KIR2.1 Forward and Backward Trafficking
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.812572
Abstract: Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associates with aberrant ion channel… read more here.
Keywords: kir2 forward; inward rectifier; kir2; cytoskeleton ... See more keywords
Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti
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DOI: 10.3390/insects9040163
Abstract: The inward rectifier potassium (Kir) channels play key roles in the physiology of mosquitoes and other insects. Our group, among others, previously demonstrated that small molecule inhibitors of Kir channels are promising lead molecules for… read more here.
Keywords: kir; kir channels; rectifier potassium; pharmacological inhibition ... See more keywords
From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel
Sign Up to like & getrecommendations! Published in 2018 at "PeerJ"
DOI: 10.7717/peerj.4680
Abstract: Background ATP-sensitive inward rectifier potassium channels (Kir), are a potassium channel family involved in many physiological processes. KATP dysfunctions are observed in several diseases such as hypoglycaemia, hyperinsulinemia, Prinzmetal angina–like symptoms, cardiovascular diseases. Methods A… read more here.
Keywords: sensitive inward; potassium channel; atp sensitive; rectifier potassium ... See more keywords