Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Gastric Cancer"
DOI: 10.1007/s10120-018-0874-2
Abstract: BackgroundRecent studies have described important roles for the sodium iodide symporter (NIS) in tumor behavior. The objectives of the present study were to investigate the role of NIS in the regulation of genes involved in… read more here.
Keywords: gastric cancer; analysis; expression; sodium iodide ... See more keywords
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00339
Abstract: Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic-pituitary-thyroid axis to potentially disrupt thyroid synthesis, transport, metabolism, and/or function. One well-known thyroid target in… read more here.
Keywords: inhibition; nis; iodide uptake; high throughput ... See more keywords
Dimerization of the Sodium/Iodide Symporter
Sign Up to like & getrecommendations! Published in 2019 at "Thyroid"
DOI: 10.1089/thy.2019.0034
Abstract: Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become… read more here.
Keywords: dimerization; sodium iodide; iodide symporter; nis ... See more keywords
TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0228794
Abstract: The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool,… read more here.
Keywords: nis expression; expression; sodium iodide; iodide symporter ... See more keywords
[18F]Tetrafluoroborate ([18F]TFB) and its analogs for PET imaging of the sodium/iodide symporter
Sign Up to like & getrecommendations! Published in 2018 at "Theranostics"
DOI: 10.7150/thno.24997
Abstract: Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS gene enabled applications of NIS as a reporter gene in both preclinical and… read more here.
Keywords: 18f tfb; 18f tetrafluoroborate; nis; iodide ... See more keywords