Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS letters"
DOI: 10.1002/1873-3468.70207
Abstract: Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy characterized by dedifferentiation and radioiodine refractoriness. We investigated whether EZH2-mediated H3K27me3 deposition represses thyroid differentiation genes (TDGs) in ATC cells. Online ChIP-seq analyses and CUT&RUN confirmed… read more here.
Keywords: iodide uptake; anaplastic thyroid; thyroid cancer; cell ... See more keywords
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00339
Abstract: Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic-pituitary-thyroid axis to potentially disrupt thyroid synthesis, transport, metabolism, and/or function. One well-known thyroid target in… read more here.
Keywords: inhibition; nis; iodide uptake; high throughput ... See more keywords
Rutin Scavenges Reactive Oxygen Species, Inactivates 5'-Adenosine Monophosphate-Activated Protein Kinase, and Increases Sodium-Iodide Symporter Expression in Thyroid PCCL3 Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Thyroid"
DOI: 10.1089/thy.2016.0585
Abstract: Background: Thyroid iodide uptake, mediated by the sodium–iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy. Therefore, compounds able to increase… read more here.
Keywords: iodide uptake; expression; pccl3; sodium iodide ... See more keywords
Regulation of thyroid sodium‐iodide symporter in different stages of goiter: Possible involvement of reactive oxygen species
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12887
Abstract: Na+/I− symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with… read more here.
Keywords: iodide uptake; r1d 21d; nis; mmi ... See more keywords
Iodide uptake by forest soils is principally related to the activity of extracellular oxidases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1105641
Abstract: 129I is a nuclear fission decay product of concern because of its long half-life (16 Ma) and propensity to bioaccumulate. Microorganisms impact iodine mobility in soil systems by promoting iodination (covalent binding) of soil organic… read more here.
Keywords: extracellular oxidases; uptake forest; iodide uptake; activity ... See more keywords