Copper-Catalyzed Regioselective Iodoformylation of Terminal Alkynes to Access Versatile Electrophiles (E)-β-Iodo-α,β-Unsaturated Aldehydes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02838
Abstract: Herein, we describe a method for synthesizing (E)-β-iodo-α,β-unsaturated aldehydes via the iodoformylation of terminal alkynes with TMSCF3 and NaI. This synthetic method uses inexpensive and easy-to-handle chemical feedstocks and employs a commercially available CuI catalyst.… read more here.
Keywords: iodo unsaturated; iodoformylation terminal; unsaturated aldehydes; terminal alkynes ... See more keywords