Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR)
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300048
Abstract: In this study we present MS Binding Assays for the PCP ion channel binding site of Torpedo californica nicotinic acetylcholine receptor (nAChR) as an alternative to radioligand binding assays. As MS Marker Benocyclidine (BTCP) was… read more here.
Keywords: pcp ion; ion channel; channel binding; binding site ... See more keywords
An improved Poisson‐Nernst‐Planck ion channel model and numerical studies on effects of boundary conditions, membrane charges, and bulk concentrations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26723
Abstract: In this paper, an improved Poisson‐Nernst‐Planck ion channel (PNPic) model is presented, along with its effective finite element solver and software package for an ion channel protein in a solution of multiple ionic species. Numerical… read more here.
Keywords: improved poisson; ion channel; model; ion ... See more keywords
8‐Br‐cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia–reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27236
Abstract: The transient receptor potential melastatin‐2 (TRPM2) channel belongs to the transient receptor potential channel superfamily and is a cation channel permeable to Na+ and Ca 2+. The TRPM2 ion channel is expressed in the kidney… read more here.
Keywords: ion channel; trpm2; ischemia reperfusion; reperfusion injury ... See more keywords
Electrophysiological and ECG Effects of Perhexiline, A Mixed Cardiac Ion Channel Inhibitor, Evaluated in Non-clinical Assays and in Healthy Subjects.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1934
Abstract: Perhexiline has been used to treat hypertrophic cardiomyopathy. In addition to its effect on carnitine-palmitoyltransferase-1, it has mixed ion channel effects through inhibition of several cardiac ion currents. Effects on cardiac ion channels expressed in… read more here.
Keywords: perhexiline; ion channel; ecg effects; ion ... See more keywords
Phase-response curves of ion channel gating kinetics
Sign Up to like & getrecommendations! Published in 2018 at "Mathematical Methods in the Applied Sciences"
DOI: 10.1002/mma.5232
Abstract: Reduced models of single-neuron dynamics are widely used to characterize neuronal properties, encoding, and a cell’s contribution to network function. Low-dimensional phase oscillator models based on phaseresponse curves, in particular, permit to capture the essence… read more here.
Keywords: gating kinetics; ion channel; phase response; response curves ... See more keywords
The transient receptor potential A1 ion channel (TRPA1) modifies in vivo autonomous ureter peristalsis in rats
Sign Up to like & getrecommendations! Published in 2020 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24579
Abstract: The current study aimed to explore the expression of transient receptor potential A1 ion channels (TRPA1) in the rat ureter and to assess if TRPA1‐active compounds modulate ureter function. read more here.
Keywords: receptor potential; ion channel; transient receptor; potential ion ... See more keywords
Ion Channel Pharmacology for Pain Modulation.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2019_336
Abstract: Ion channels, due to their prominent localization in primary sensory neurons and other key structures in pain processing, are regarded as a major class of drug targets for modulating pain sensation and controlling chronic pain.… read more here.
Keywords: ion channels; ion channel; pharmacology; ion ... See more keywords
Bioluminescence Methodology for Ion Channel Studies.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0818-0_10
Abstract: As key players in cell function, ion channels are important targets for drug discovery and therapeutic development against a wide range of health conditions. Thus, developing assays to reconstitute ion channel macromolecular complexes in physiological… read more here.
Keywords: drug discovery; methodology; ion; ion channel ... See more keywords
Applications for Mass Spectrometry in the Study of Ion Channel Structure and Function.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-15950-4_20
Abstract: Ion channels are intrinsic membrane proteins that form gated ion permeable pores across biological membranes. Depending on the type, ion channels exhibit sensitivities to a diverse range of stimuli including changes in membrane potential, binding… read more here.
Keywords: mass spectrometry; ion channels; ion channel; ion ... See more keywords
Vacuolar ion channels in the liverwort Marchantia polymorpha: influence of ion channel inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Planta"
DOI: 10.1007/s00425-017-2661-4
Abstract: AbstractMain conclusionPotassium-permeable slow activating vacuolar channels (SV) and chloride-permeable channels in the vacuole of the liverwortMarchantia polymorphawere characterized in respect to calcium dependence, selectivity, and pharmacology. The patch-clamp method was used in the study of… read more here.
Keywords: permeable channels; channel inhibitors; ion channel; channel ... See more keywords
Memory in Ion Channel Kinetics.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biotheoretica"
DOI: 10.1007/s10441-021-09415-1
Abstract: Ion channels are transport proteins present in the lipid bilayers of biological membranes. They are involved in many physiological processes, such as the generation of nerve impulses, hormonal secretion, and heartbeat. Conformational changes in the… read more here.
Keywords: channel kinetics; ion channel; memory ion; channel ... See more keywords