Ionic mechanisms of the action of anaesthetics on sinoatrial node automaticity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.08.006
Abstract: ABSTRACT Although various general anaesthetics affect the heart rate in clinical settings, their precise mechanisms remain to be fully elucidated. Because the heart rate is determined by automaticity of the cardiac pacemaker sinoatrial node and… read more here.
Keywords: sinoatrial node; anaesthetics sinoatrial; node automaticity; ionic mechanisms ... See more keywords
The radical versus ionic mechanisms of reduced cobalamin inactivation by tert-butyl hydroperoxide and hydrogen peroxide in aqueous solution
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DOI: 10.1039/d0nj04231e
Abstract: It was demonstrated that antioxidants cannot protect reduced cobalamin against its modification by hydrogen peroxide. read more here.
Keywords: hydrogen peroxide; ionic mechanisms; versus ionic; radical versus ... See more keywords
Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin‐2
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DOI: 10.1111/bph.14183
Abstract: Optogenetic control of electromechanical coupling in vascular smooth muscle cells (VSMCs) is emerging as a powerful research tool with potential applications in drug discovery and therapeutics. However, the precise ionic mechanisms involved in this control… read more here.
Keywords: control; ionic mechanisms; control vascular; mechanisms optogenetic ... See more keywords
Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart
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DOI: 10.1161/circresaha.120.317349
Abstract: Supplemental Digital Content is available in the text. Rationale: FHFs (fibroblast growth factor homologous factors) are key regulators of sodium channel (NaV) inactivation. Mutations in these critical proteins have been implicated in human diseases including… read more here.
Keywords: propagation; ionic mechanisms; fhf2 deficient; nav inactivation ... See more keywords
Combinatorial Therapy of Cancer: Possible Advantages of Involving Modulators of Ionic Mechanisms
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DOI: 10.3390/cancers14112703
Abstract: Simple Summary Cancer, which is a major health problem, is a complex disease. Currently, the main treatment methods are surgery, chemotherapy, radiotherapy and biological therapies. The latter include hormonal therapies, inhibitors of growth-promoting tyrosine kinase… read more here.
Keywords: ionic mechanisms; modulators ionic; side effects; undesirable side ... See more keywords