Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12893
Abstract: Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nonviral platform for mRNA delivery. While they have been explored for applications including vaccines and gene editing, LNPs have not been investigated for placental insufficiency during… read more here.
Keywords: mrna delivery; placenta; ionizable lipid; pregnancy ... See more keywords
Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02441-2
Abstract: Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we report a… read more here.
Keywords: administration; intravascular administration; intramuscular intravascular; expression ... See more keywords
Boosting ionizable lipid nanoparticle-mediated in vivo mRNA delivery through optimization of lipid amine-head groups.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm00866h
Abstract: In vitro transcribed messenger RNA (IVT-mRNA) holds great promise for the development of novel therapeutics, such as immunotherapy and vaccination. However, the main obstacle towards clinical translation is the lack of effective delivery systems. Herein,… read more here.
Keywords: head; ilnp; delivery; amine head ... See more keywords
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement
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DOI: 10.1080/17425247.2023.2153832
Abstract: ABSTRACT Introduction Ionizable lipid nanoparticles (LNPs) have been proven to have high encapsulation, cellular uptake, and effective endosomal escape and are therefore promising for nucleic acid delivery. The combination of ionizable lipids, helper lipids, cholesterol,… read more here.
Keywords: ionizable lnps; technology; ionizable lipid; acid ionizable ... See more keywords
Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia
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DOI: 10.1126/sciadv.abm1418
Abstract: Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment of a thermostable clinically applicable delivery system remains a most challenging issue for siRNA drug development. Here,… read more here.
Keywords: treatment hyperlipidemia; lipid like; hyperlipidemia; ionizable lipid ... See more keywords
Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes
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DOI: 10.2147/ijn.s366962
Abstract: Introduction Gene therapy is a promising approach to be applied in cardiac regeneration after myocardial infarction and gene correction for inherited cardiomyopathies. However, cardiomyocytes are crucial cell types that are considered hard-to-transfect. The entrapment of… read more here.
Keywords: nanoparticle mediated; ionizable lipid; lipid nanoparticle; treatment ... See more keywords
The development of highly dense highly protected surfactant ionizable lipid RNA loaded nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1129296
Abstract: The long quest for efficient drug administration has been looking for a universal carrier that can precisely transport traditional drugs, new genomic and proteic therapeutic agents. Today, researchers have found conditions to overcome the two… read more here.
Keywords: development highly; development; ionizable lipid; drug delivery ... See more keywords