Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202209624
Abstract: Lipid nanoparticles (LNPs) have proven a successful platform for the delivery of nucleic acid (NA)‐based therapeutics and vaccines, with the ionizable lipid component playing a key role in modulating potency and tolerability. Here, a library… read more here.
Keywords: unsaturated trialkyl; ionizable lipids; vaccine applications; trialkyl ionizable ... See more keywords
Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10670
Abstract: Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines. Functional delivery of mRNA by an LNP greatly depends… read more here.
Keywords: mrna delivery; iterative design; intramuscular mrna; ionizable lipids ... See more keywords
Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28104046
Abstract: Ionizable lipid-containing lipid nanoparticles (LNPs) as a non-viral vector with good safety and potency have been considered as an ideal delivery system for gene therapy. The screening of ionizable lipid libraries with common features but… read more here.
Keywords: mrna delivery; click reaction; ionizable lipids; triazole moiety ... See more keywords