A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement
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DOI: 10.1080/17425247.2023.2153832
Abstract: ABSTRACT Introduction Ionizable lipid nanoparticles (LNPs) have been proven to have high encapsulation, cellular uptake, and effective endosomal escape and are therefore promising for nucleic acid delivery. The combination of ionizable lipids, helper lipids, cholesterol,… read more here.
Keywords: ionizable lnps; technology; ionizable lipid; acid ionizable ... See more keywords
Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2023.2162876
Abstract: ABSTRACT Introduction Messenger ribonucleic acid (mRNA) and small interfering RNA (siRNA) are biological molecules that can be heated, frozen, lyophilized, precipitated, or re-suspended without degradation. Currently, ionizable lipid nanoparticles (LNPs) are a promising approach for… read more here.
Keywords: life; storage; ionizable lnps; mrna ionizable ... See more keywords