Desorption Electrospray Ionization Mass Spectrometry Assay for Label‐Free Characterization of SULT2B1b Enzyme Kinetics
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200043
Abstract: The sulfotransferase (SULT) 2B1b, which catalyzes the sulfonation of 3β‐hydroxysteroids, has been identified as a potential target for prostate cancer treatment. However, a major limitation for SULT2B1b‐targeted drug discovery is the lack of robust assays… read more here.
Keywords: label free; sult2b1b; mass spectrometry; desorption electrospray ... See more keywords
High‐Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2025 at "Chempluschem"
DOI: 10.1002/cplu.202500164
Abstract: Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should expedite drug discovery. Herein, the applicability of HT desorption electrospray ionization mass spectrometry (DESI MS) to achieve late‐stage… read more here.
Keywords: desorption electrospray; high throughput; mass spectrometry; ionization mass ... See more keywords
Lipidomic study and diagnosis of hepatocellular carcinoma tumor with rapid evaporative ionization mass spectrometry.
Sign Up to like & getrecommendations! Published in 2023 at "Electrophoresis"
DOI: 10.1002/elps.202300007
Abstract: Liver cancer is generally considered the leading cause of cancer deaths worldwide, and hepatocellular carcinoma (HCC) contributes to more than 90% of liver cancers. The altered lipid metabolism for rapid cancer cell growth and tumor… read more here.
Keywords: mass spectrometry; tumor; ionization mass; mass ... See more keywords
Rapid evaporative ionization mass spectrometry: A survey through 15 years of applications.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of separation science"
DOI: 10.1002/jssc.202400155
Abstract: Rapid evaporative ionization mass spectrometry (REIMS) is a relatively recent MS technique explored in many application fields, demonstrating high versatility in the detection of a wide range of chemicals, from small molecules (phenols, amino acids,… read more here.
Keywords: evaporative ionization; rapid evaporative; ionization mass; mass spectrometry ... See more keywords
The Use of Acoustic Mist Ionization Mass Spectrometry for High-Throughput Screening.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1197-5_9
Abstract: It is clear from the analysis of the distribution of approved drug targets that enzymes continue to be a major target class for the pharmaceutical industry. The application of high-throughput screens designed to monitor the… read more here.
Keywords: mist ionization; mass spectrometry; throughput; high throughput ... See more keywords
Surface tuning laser desorption/ionization mass spectrometry (STLDI-MS) for the analysis of small molecules using quantum dots
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0433-4
Abstract: In most applications of quantum dots (QDs) for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS), one side of QDs is supported by a solid substrate (stainless - steel plate), whereas the other side is in contact… read more here.
Keywords: mass spectrometry; ionization mass; laser desorption; ionization ... See more keywords
Uranium age-dating using in-situ isotope ratios by thermal ionization mass spectrometry for nuclear forensics
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-017-5379-7
Abstract: The model dates of two enriched uranium materials were determined using a new method for nuclear forensics investigation. In this method, without spike addition, the 230Th/234U ratio was calculated from the measured ratios of 230Th/234Th… read more here.
Keywords: date; ionization mass; nuclear forensics; thermal ionization ... See more keywords
Ambient ionization mass spectrometry imaging for disease diagnosis: Excitements and challenges
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biosciences"
DOI: 10.1007/s12038-018-9785-y
Abstract: Tissue analysis in histology is extremely important and also considered to be a gold standard to diagnose and prognosticate several diseases including cancer. Intraoperative evaluation of surgical margin of tumor also relies on frozen section… read more here.
Keywords: mass spectrometry; ambient ionization; histopathology; ionization mass ... See more keywords
Nitrogen abundance and isotope analysis of silicate glasses by secondary ionization mass spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Geology"
DOI: 10.1016/j.chemgeo.2018.06.008
Abstract: Chondritic meteorites preserve extreme intra-sample 15N/14N variations, which exceed, in some cases, the range of nitrogen isotope ratios observed at the Solar System scale. These observations are based on in situ analyses of CN− molecular… read more here.
Keywords: nitrogen; secondary ionization; mass; silicate ... See more keywords
Two-color resonance enhanced multi-photon ionization and mass analyzed threshold ionization spectroscopy of 2-aminobenzonitrile and the CN substitution effect
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2017.12.073
Abstract: Abstract Two-color resonance two-photon ionization and mass analyzed threshold ionization spectra of 2-aminobenzonitrile have been obtained. The band origin of the S 1 ← S 0 transition and the precise ionization energy (IE) were determined… read more here.
Keywords: photon ionization; two color; ionization mass; spectroscopy ... See more keywords
Resonance enhanced multiphoton ionization and mass analyzed threshold ionization spectroscopy of 4-fluorobenzonitrile
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2018.09.039
Abstract: Abstract The vibrational features of 4-fluorobenzonitrile in the first electronically excited state S1 and cationic ground state D0 have been studied by two-color resonance enhanced multiphoton ionization and mass analyzed threshold ionization spectroscopy. Most of… read more here.
Keywords: resonance enhanced; ionization mass; spectroscopy; multiphoton ionization ... See more keywords