Synthesis of an allosteric modulator of ionotropic glutamate receptors
Sign Up to like & getrecommendations! Published in 2020 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2020.03.008
Abstract: Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range… read more here.
Keywords: allosteric modulator; modulator ionotropic; glutamate receptors; ionotropic glutamate ... See more keywords
Design and Synthesis of 2,3- trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00205
Abstract: Development of pharmacological tools for the ionotropic glutamate receptors (iGluRs) is imperative for the study and understanding of the role and function of these receptors in the central nervous system. We report the synthesis of… read more here.
Keywords: acid; amino acid; excitatory amino; ionotropic glutamate ... See more keywords
Post‐translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15050
Abstract: In the mammalian CNS, glutamate is the major excitatory neurotransmitter. Ionotropic glutamate receptors (iGluRs) are responsible for the glutamate‐mediated postsynaptic excitation of neurons. Regulation of glutamatergic synapses is critical for higher brain functions including neural… read more here.
Keywords: palmitoylation; post translational; ionotropic glutamate; glutamate receptors ... See more keywords
Simulation Analysis of Temporal Coding by Ionotropic Glutamate Receptors of Retinal OFF-type Bipolar Cells
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DOI: 10.18494/sam.2018.1720
Abstract: OFF-type bipolar cells (OFF-BCs) are interneurons connecting cone and retinal ganglion cells in the retina. In the mammalian retina, the cone signals are received by alpha-amino3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate-type ionotropic glutamate receptors (iGluRs) in OFF-BCs. The… read more here.
Keywords: type bipolar; bipolar cells; glutamate receptors; type ... See more keywords
Pathophysiological Ionotropic Glutamate Signalling in Neuroinflammatory Disease as a Therapeutic Target
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DOI: 10.3389/fnins.2021.741280
Abstract: Glutamate signalling is an essential aspect of neuronal communication involving many different glutamate receptors, and underlies the processes of memory, learning and synaptic plasticity. Despite neuroinflammatory diseases covering a range of maladies with very different… read more here.
Keywords: glutamate signalling; signalling neuroinflammatory; ionotropic glutamate; glutamate ... See more keywords
Ultrarare Loss-of-Function Mutations in the Genes Encoding the Ionotropic Glutamate Receptors of Kainate Subtypes Associated with Schizophrenia Disrupt the Interaction with PSD95
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050783
Abstract: Schizophrenia is a complex mental disorder with a genetic component. The GRIK gene family encodes ionotropic glutamate receptors of the kainate subtype, which are considered candidate genes for schizophrenia. We screened for rare and pathogenic… read more here.
Keywords: receptors kainate; function; loss function; interaction psd95 ... See more keywords