LAUSR

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

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1 Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03091-8

Abstract: Bcl-2 proteins have emerged as critical regulators of intracellular Ca2+ dynamics by directly targeting and inhibiting the IP3 receptor (IP3R), a major intracellular Ca2+-release channel. Here, we demonstrate that such inhibition occurs under conditions of basal,… read more here.

Keywords: bh4 domain; ligand binding; ip3; ca2 ... See more keywords

Intercellular Bridge Mediates Ca2+ Signals between Micropatterned Cells via IP3 and Ca2+ Diffusion.

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1 Published in 2020 at "Biophysical journal"

DOI: 10.1016/j.bpj.2020.01.006

Abstract: Intercellular bridges are plasma continuities formed at the end of the cytokinesis process that facilitate intercellular mass transport between the two daughter cells. However, it remains largely unknown how the intercellular bridge mediates Ca2+ communication… read more here.

Keywords: intercellular bridge; ip3; ca2; ca2 diffusion ... See more keywords

Probes for manipulating and monitoring IP3.

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0 Published in 2017 at "Cell calcium"

DOI: 10.1016/j.ceca.2016.11.003

Abstract: Inositol 1,4,5-trisphosphate (IP3) is an important second messenger produced via G-protein-coupled receptor- or receptor tyrosine kinase-mediated pathways. IP3 levels induce Ca2+ release from the endoplasmic reticulum (ER) via IP3 receptor (IP3R) located in the ER… read more here.

Keywords: manipulating monitoring; monitoring ip3; ip3; receptor ... See more keywords

Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons.

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0 Published in 2021 at "Cell calcium"

DOI: 10.1016/j.ceca.2021.102399

Abstract: Neuronal Ca2+ signals are fundamental for synaptic transmission and activity-dependent changes in gene expression. Voltage-gated Ca2+ channels and N-methyl-d-aspartate receptors play major roles in mediating external Ca2+ entry during action potential firing and glutamatergic activity.… read more here.

Keywords: ca2 signals; ca2 release; ip3; ca2 ... See more keywords

IP3 receptors – lessons from analyses ex cellula

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1 Published in 2018 at "Journal of Cell Science"

DOI: 10.1242/jcs.222463

Abstract: ABSTRACT Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular channels that release Ca2+ from the endoplasmic reticulum (ER). We review how studies of IP3Rs removed from their intracellular environment (‘ex cellula’), alongside similar analyses of… read more here.

Keywords: structural analyses; ip3; ca2; receptors lessons ... See more keywords