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   Articles with "ip3 receptors" as a keyword



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Impairments in remote memory caused by the lack of Type 2 IP3 receptors

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recommendations! Published in 2019 at "Glia"

DOI: 10.1002/glia.23679

Abstract: The second messenger inositol 1,4,5‐trisphosphate (IP3) is paramount for signal transduction in biological cells, mediating Ca2+ release from the endoplasmic reticulum. Of the three isoforms of IP3 receptors identified in the nervous system, Type 2… read more here.

Keywords: memory; long term; lack; impairments remote ... See more keywords
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IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes

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recommendations! Published in 2018 at "Cell Reports"

DOI: 10.1016/j.celrep.2018.11.064

Abstract: Summary Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistribute Ca2+ from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H+-ATPase (V-ATPase) inhibitors, that lysosomes sequester… read more here.

Keywords: preferentially associate; lysosome contact; associate lysosome; ca2 ... See more keywords
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KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-24739-9

Abstract: Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile IP3Rs,… read more here.

Keywords: ca2 signals; krap tethers; ca2 puffs; ca2 ... See more keywords
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Structure and Function of IP3 Receptors.

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recommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"

DOI: 10.1101/cshperspect.a035063

Abstract: Inositol 1,4,5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or other organelles, and they initiate store-operated Ca2+ entry… read more here.

Keywords: function ip3; structure function; ip3 receptors; ca2 ... See more keywords
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IP3 receptors – lessons from analyses ex cellula

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recommendations! Published in 2018 at "Journal of Cell Science"

DOI: 10.1242/jcs.222463

Abstract: ABSTRACT Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular channels that release Ca2+ from the endoplasmic reticulum (ER). We review how studies of IP3Rs removed from their intracellular environment (‘ex cellula’), alongside similar analyses of… read more here.

Keywords: structural analyses; ip3; ca2; receptors lessons ... See more keywords