Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-018-1522-7
Abstract: BackgroundInositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of intracellular Ca2+ release channels located on the membrane of endoplasmic reticulum, which have been shown to play critical roles in various cellular and physiological functions. However, their… read more here.
Keywords: pcr1ko mice; ip3r1; pdgfrb cre; tract ... See more keywords
Acetylcholine attenuated TNF-α-induced intracellular Ca2+ overload by inhibiting the formation of the NCX1-TRPC3-IP3R1 complex in human umbilical vein endothelial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.04.001
Abstract: The endoplasmic reticulum (ER) forms discrete junctions with the plasma membrane (PM) that play a critical role in the regulation of Ca2+ signaling during cellular bioenergetics, apoptosis and autophagy. We have previously confirmed that acetylcholine… read more here.
Keywords: ip3r1 complex; ip3r1; endothelial cells; ca2 ... See more keywords
IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00404-4
Abstract: Intracellular ion channel inositol 1,4,5-triphosphate receptor (IP3R1) releases Ca 2+ from endoplasmic reticulum. The disturbance of IP3R1 is related to several neurodegenerative diseases. This study investigated the mechanism of IP3R1 in myocardial ischemia/reperfusion (MI/R). After… read more here.
Keywords: nlrp3 caspase; ip3r1; pyroptosis; reperfusion ... See more keywords
Loss- and gain-of-function mutations in the Type 1 IP3 receptor (IP3R1) affect myogenic constriction of murine cerebral resistance arteries
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731469
Abstract: Myogenic reactivity in resistance arteries/arterioles in response to changing intraluminal pressure is a key physiological mechanism for the regulation of blood pressure and flow. Although IP3-mediated intracellular Ca2+ release is known to contribute to the… read more here.
Keywords: function; mmhg; resistance arteries; pressure ... See more keywords