A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2018.12.004
Abstract: The parasitic protozoon Trichomonas vaginalis is the pathogen of trichomoniasis, the most common non-viral, sexually transmitted disease in humans. Inositol phosphates function in the pathomechanisms of a number of human pathogenic protozoa. Recent findings point… read more here.
Keywords: protozoon trichomonas; kinase; novel pyrophosphorylating; trichomonas vaginalis ... See more keywords
Atomic-scale characterization of mature HIV-1 capsid stabilization by inositol hexakisphosphate (IP6)
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc6465
Abstract: All-atom simulations reveal the molecular mechanisms of inositol hexakisphosphate binding to HIV capsids. Inositol hexakisphosphates (IP6) are cellular cofactors that promote the assembly of mature capsids of HIV. These negatively charged molecules coordinate an electropositive… read more here.
Keywords: inositol hexakisphosphate; hiv; atomic scale; capsid ... See more keywords