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Published in 2020 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2019-0303oc
Abstract: The extracellular matrix (ECM) increasingly emerges as an active driver in several diseases, including idiopathic pulmonary arterial hypertension (IPAH). The basement membrane (BM) is a specialized class of ECM proteins. In pulmonary arteries, the BM…
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Keywords:
ipah;
basement membrane;
pulmonary arterial;
arterial hypertension ... See more keywords
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Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.01609-2018
Abstract: Background Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease with high heritability. Although several predisposing genes have been linked to IPAH, the genetic aetiology remains unknown for a large number of IPAH cases. Methods…
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Keywords:
idiopathic pulmonary;
arterial hypertension;
pulmonary arterial;
gene ... See more keywords
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Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa3082
Abstract: Introduction: Idiopathic pulmonary arterial hypertension (iPAH) is a rare, life-shortening disease. Symptoms are non-specific with diagnosis usually made at a late stage. Aims and objectives: The study aim was to develop a predictive algorithm (Sheffield…
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Keywords:
real world;
idiopathic pulmonary;
arterial hypertension;
pulmonary arterial ... See more keywords
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Published in 2022 at "ERJ Open Research"
DOI: 10.1183/23120541.00549-2021
Abstract: Background Patients with pulmonary hypertension (PH) and lung disease may pose a diagnostic dilemma between idiopathic pulmonary arterial hypertension (IPAH) and PH associated with lung disease (PH-CLD). The prognostic impact of common computed tomography (CT)…
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Keywords:
lung;
lung disease;
lung parenchymal;
disease ... See more keywords
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Published in 2021 at "Genes"
DOI: 10.3390/genes12010125
Abstract: Gene dysfunction and immune cell infiltration play an essential role in the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). We aimed to investigate the immune landscape and novel differentially expressed genes (DEGs) of IPAH. In…
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Keywords:
idiopathic pulmonary;
pulmonary arterial;
immune landscape;
gene ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126508
Abstract: Pulmonary arterial hypertension (PAH) is rare disease that is categorized as idiopathic (IPAH) when no underlying cause can be identified. Lungs of most patients with IPAH contain increased numbers of T cells and dendritic cells…
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Keywords:
ipah;
reduced cytokine;
peripheral blood;
ipah patients ... See more keywords