Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence
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DOI: 10.1038/nature24467
Abstract: Interferon-inducible guanylate-binding proteins (GBPs) mediate cell-autonomous antimicrobial defences. Shigella flexneri, a Gram-negative cytoplasmic free-living bacterium that causes bacillary dysentery, encodes a repertoire of highly similar type III secretion system effectors called invasion plasmid antigen Hs… read more here.
Keywords: degradation; gbps; defence; ipah9 ... See more keywords