IPMK modulates hepatic glucose production and insulin signaling
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DOI: 10.1002/jcp.30827
Abstract: Hepatic glucose production (HGP) is crucial for the maintenance of normal glucose homeostasis. Although hepatic insulin resistance contributes to excessive glucose production, its mechanism is not well understood. Here, we show that inositol polyphosphate multikinase… read more here.
Keywords: ipmk; hepatic glucose; insulin signaling; glucose production ... See more keywords
Abstract B010: Determining the cancer cell sensitivity to IPMK-ATP competitive inhibitors
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DOI: 10.1158/1538-7445.canevol25-b010
Abstract: Human inositol phosphate multikinase (IPMK) is an inositol kinase that plays a significant role in many cellular processes. IPMK activity is required for the production of all higher-order inositol phosphate species (IP5, IP6, IP7 and… read more here.
Keywords: cancer; determining cancer; cell lines; cell ... See more keywords
The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub
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DOI: 10.14348/molcells.2017.0066
Abstract: The inositol polyphosphates are a group of multifunctional signaling metabolites whose synthesis is catalyzed by a family of inositol kinases that are evolutionarily conserved from yeast to humans. Inositol polyphosphate multikinase (IPMK) was first identified… read more here.
Keywords: inositol; inositol polyphosphate; expanding significance; polyphosphate multikinase ... See more keywords
294-OR: The Role of Inositol Polyphosphate Multikinase in Progression of Nonalcoholic Steatohepatitis
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DOI: 10.2337/db24-294-or
Abstract: Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease globally, ranging from simple steatosis to the advanced stage of nonalcoholic steatohepatitis (NASH). Despite ongoing clinical trials exploring NAFLD treatments, there are… read more here.
Keywords: nafld nash; inositol polyphosphate; role; progression ... See more keywords
From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
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DOI: 10.3390/biom15091266
Abstract: Once a protein of relative obscurity, inositol polyphosphate multikinase (IPMK) emerged as a versatile and indispensable enzyme in cellular biology. With dual inositol and lipid kinase activities, IPMK generates pivotal signaling molecules such as InsP4… read more here.
Keywords: disease; obscurity prominence; physiology; ipmk ... See more keywords