From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28387
Abstract: Parkinson's disease (PD) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. However, it is now widely recognized that PD is… read more here.
Keywords: cells rodents; movement; parkinson; ips cells ... See more keywords
The Number of Point Mutations In iPS Cells and ntES Cells Depends on the Method and Somatic Cell Type Employed for Their Generation.
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells"
DOI: 10.1002/stem.2601
Abstract: Induced pluripotent stem cells hold great promise for regenerative medicine but point mutations have been identified in these cells and have raised serious concerns about their safe use. We generated nucleartransfer ES cells (ntESCs) from… read more here.
Keywords: medicine; point mutations; ips cells; number ... See more keywords
Generation of Murine Induced Pluripotent Stem Cells through Transposon-Mediated Reprogramming.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/7651_2021_350
Abstract: The seminal discovery of induced pluripotent stem (iPS) cells through ectopic expression of a cocktail of gene factors (OCT4, SOX2, KLF4, and c-MYC) by the group of Yamanaka was a major breakthrough, gained widespread acclaim… read more here.
Keywords: ips cells; generation; pluripotent stem; induced pluripotent ... See more keywords
Human gingival fibroblast feeder cells promote maturation of induced pluripotent stem cells into cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.116
Abstract: The use of human induced pluripotent stem (iPS) cells has been investigated in multiple regenerative medicine studies. However, although methods for efficient differentiation of iPS cells into heart tissues have been devised, it remains difficult… read more here.
Keywords: feeder cells; ips cells; pluripotent stem; induced pluripotent ... See more keywords
SU105 MODELING SCHIZOPHRENIA IN VITRO BY THE GENERATION OF NEURONS FROM PATIENT-SPECIFIC STEM CELLS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.294
Abstract: Background Schizophrenia is a neurodevelopmental disease. Causes include environmental and genetic factors. Characteristics of schizophrenia include a deregulation of the glutamatergic and the GABAergic neurotransmission and the degeneration of predominantly inhibitory interneurons. Recently, 108 loci… read more here.
Keywords: schizophrenia; patient specific; analysis; ips cells ... See more keywords
M89 MODELING HUMAN CORTICAL BRAIN DEVELOPMENT BY THE GENERATION OF CEREBRAL ORGANOIDS FROM PATIENT-SPECIFIC STEM CELLS FOR THE ANALYSIS OF SCHIZOPHRENIA GENETICS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.396
Abstract: Background Characteristics of schizophrenia include the deregulation of the glutamatergic and the GABAergic neurotransmission and the degeneration of predominantly inhibitory interneurons within the cortex of the human brain. Cortical development was extensively studied in rodents,… read more here.
Keywords: patient specific; ips cells; analysis; human cortical ... See more keywords
Induction of functional islet-like cells from human iPS cells by suspension culture
Sign Up to like & getrecommendations! Published in 2019 at "Regenerative Therapy"
DOI: 10.1016/j.reth.2018.11.003
Abstract: Introduction To complement islet transplantation for type1 diabetic patients, cell-based therapy using pluripotent stem cells such as ES cells and iPS cells is promising. Many papers have already reported the induction of pancreatic β cells… read more here.
Keywords: suspension culture; ips cells; like cells; human ips ... See more keywords
Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2016.10.012
Abstract: Schizophrenia is a chronic psychiatric disorder with complex genetic and environmental origins. While many antipsychotics have been demonstrated as effective in the treatment of schizophrenia, a substantial number of schizophrenia patients are partially or fully… read more here.
Keywords: schizophrenia; treatment resistant; monozygotic twin; ips cells ... See more keywords
A stress-free strategy to correct point mutations in patient iPS cells
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell research"
DOI: 10.1016/j.scr.2021.102332
Abstract: When studying patient specific induced pluripotent stem cells (iPS cells) as a disease model, the ideal control is an isogenic line that has corrected the point mutation, instead of iPS cells from siblings or other… read more here.
Keywords: methodology; point mutation; ips cells; patient ips ... See more keywords
Global transcriptome analysis of pig induced pluripotent stem cells derived from six and four reprogramming factors
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Data"
DOI: 10.1038/sdata.2019.34
Abstract: Pigs are important, both for agriculture and as animal models for human diseases. However, due to the lack of embryonic stem cells, the possibility of genetic modification is quite limited. To overcome this limitation, induced… read more here.
Keywords: pig; ips cells; pluripotent stem; induced pluripotent ... See more keywords
Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45577
Abstract: Induced pluripotent stem (iPS) cells hold great potential for being a major source of cells for regenerative medicine. One major issue that hinders their advancement to clinic is the persistence of undifferentiated iPS cells in… read more here.
Keywords: viability; ips cells; without affecting; ips derived ... See more keywords