Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45577
Abstract: Induced pluripotent stem (iPS) cells hold great potential for being a major source of cells for regenerative medicine. One major issue that hinders their advancement to clinic is the persistence of undifferentiated iPS cells in… read more here.
Keywords: viability; ips cells; without affecting; ips derived ... See more keywords
iPS‐derived pericytes for neurovascular regeneration
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DOI: 10.1111/eci.13601
Abstract: Pericytes are key components of the blood brain barrier (BBB) and are involved in major neurological disorders including stroke. Now, Sun and colleagues demonstrate that transplantation of pericytes reconstructs the BBB integrity and enhances functional… read more here.
Keywords: neurovascular regeneration; ips derived; pericytes neurovascular; derived pericytes ... See more keywords
Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo
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DOI: 10.1126/sciadv.abc6983
Abstract: MS-derived oligodendrocytes conserve their ability to fully interact with axons and glial cells in vivo. Remyelination failure in multiple sclerosis (MS) is associated with a migration/differentiation block of oligodendroglia. The reason for this block is… read more here.
Keywords: sclerosis ips; interact axons; oligodendroglia conserve; derived oligodendroglia ... See more keywords
Generation of iPS-derived model cells for analyses of hair shaft differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "BioTechniques"
DOI: 10.2144/000114589
Abstract: Biological evaluation of hair growth/differentiation activity in vitro has been a formidable challenge, primarily due to the lack of relevant model cell systems. To solve this problem, we generated a stable model cell line in… read more here.
Keywords: hair; ips derived; differentiation; generation ips ... See more keywords