Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-03047-1
Abstract: IntroductionIDH1 mutation has been identified as an early genetic event driving low grade gliomas (LGGs) and it has been proven to exerts a powerful epigenetic effect. Cells containing IDH1 mutation are refractory to epigenetical reprogramming… read more here.
Keywords: ipsc clones; regional chromosomal; idh1 mutation; grade gliomas ... See more keywords
Selection of iPSCs without mtDNA deletion for autologous cell therapy in a patient with Pearson syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "BMB reports"
DOI: 10.5483/bmbrep.2022-0204
Abstract: Screening for genetic defects in the cells should be examined for clinical application. The Pearson syndrome (PS) patient harbored nuclear mutations in the POLG and SSBP1 genes, which could induce systemic large-scale mitochondrial genome (mtDNA)… read more here.
Keywords: mtdna deletion; deletion; pearson syndrome; autologous cell ... See more keywords