Functional evaluation of the tachycardia patient‐derived iPSC cardiomyocytes carrying a novel pathogenic SCN5A variant
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30843
Abstract: Tachycardia is characterized by high beating rates that can lead to life‐threatening fibrillations. Mutations in several ion‐channel genes were implicated with tachycardia; however, the complex genetic contributors and their modes of action are still unclear.… read more here.
Keywords: scn5a; ipsc cms; tachycardia; derived ipsc ... See more keywords
Modeling the human heart ex vivo—current possibilities and strive for future applications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3335
Abstract: The high organ specification of the human heart is inversely proportional to its functional recovery after damage. The discovery of induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) has accelerated research in human heart regeneration and physiology.… read more here.
Keywords: human heart; vivo; ipsc cms; physiology ... See more keywords
Targeting the Cardiac Sodium Channel to Increase Excitability of Stem-Cell Derived Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.138
Abstract: The cardiogenic potential of stem-cell derived cardiomyocytes (iPSC-CM) and their prospective use for cardiac cell therapy crucially depends on their excitability and functional integration in myocardial tissue. Indeed, previous studies from our group have shown… read more here.
Keywords: expression; excitability; ipsc cms; cx43 ... See more keywords
Comparative Gene Expression Analyses Reveal Distinct Molecular Signatures between Differentially Reprogrammed Cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.005
Abstract: Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) or directly reprogrammed from non-myocytes (induced cardiomyocytes [iCMs]) are promising sources for heart regeneration or disease modeling. However, the similarities and differences between iPSC-CMs and iCMs are… read more here.
Keywords: cms icms; ipsc cms; gene expression;
Genetic variants in calcium regulatory cardiac genes and their contribution to Takotsubo syndrome
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3712
Abstract: Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction similar to a myocardial infarction (MI) in the absence of coronary artery stenosis. Patients show symptoms similar to the acute MI with increased biomarkers… read more here.
Keywords: ahnak; tts; tts ipsc; ipsc cms ... See more keywords
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac305
Abstract: AIMS Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translating to… read more here.
Keywords: serine biosynthesis; ipsc cms; dcm ipsc; dcm ... See more keywords
Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szac061
Abstract: Abstract The development of new cardioprotective approaches using in vivo models of ischemic heart disease remains challenging as differences in cardiac physiology, phenotype, and disease progression between humans and animals influence model validity and prognostic… read more here.
Keywords: metabolic maturation; ipsc cms; hypoxia; cms ... See more keywords
Alternative splicing signatures of congenital heart disease and induced pluripotent stem cell-derived cardiomyocytes from congenital heart disease patients
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030123
Abstract: Congenital heart disease (CHD) is the most serious congenital defect in newborns with higher mortality. Alternative splicing (AS) plays an essential role in numerous heart diseases. However, our understanding of the link between mRNA splicing… read more here.
Keywords: ipsc cms; congenital heart; heart; chd ... See more keywords
Electrophysiological abnormalities in induced pluripotent stem cell‐derived cardiomyocytes generated from Duchenne muscular dystrophy patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14124
Abstract: Duchenne muscular dystrophy (DMD) is an X‐linked progressive muscle degenerative disease, caused by mutations in the dystrophin gene and resulting in death because of respiratory or cardiac failure. To investigate the cardiac cellular manifestation of… read more here.
Keywords: muscular dystrophy; ipsc cms; ipsc; induced pluripotent ... See more keywords
Efficacy of RyR2 inhibitor EL20 in induced pluripotent stem cell‐derived cardiomyocytes from a patient with catecholaminergic polymorphic ventricular tachycardia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16521
Abstract: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac arrhythmia syndrome that often leads to sudden cardiac death. The most common form of CPVT is caused by autosomal‐dominant variants in the cardiac ryanodine receptor type‐2… read more here.
Keywords: el20; ventricular tachycardia; polymorphic ventricular; ryr2 ... See more keywords
Activation of PDGFRA signaling contributes to filamin C–related arrhythmogenic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abk0052
Abstract: FLNC truncating mutations (FLNCtv) are prevalent causes of inherited dilated cardiomyopathy (DCM), with a high risk of developing arrhythmogenic cardiomyopathy. We investigated the molecular mechanisms of mutant FLNC in the pathogenesis of arrhythmogenic DCM (a-DCM)… read more here.
Keywords: pdgfra signaling; activation pdgfra; ipsc cms; arrhythmogenic cardiomyopathy ... See more keywords