Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age‐ and Estrogen‐Dependent Bone Loss in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4800
Abstract: Osteoporosis is a common bone disease caused by an imbalance of bone resorption and formation that results in a loss of total bone density. SMAD2/3 signal transduction is known to play a crucial role in… read more here.
Keywords: bone; loss; osteoporosis; higenamine promotes ... See more keywords
Site-specific expression of IQGAP1 in human nephrons
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-019-09811-5
Abstract: IQGAP1 is a multifunctional, 190-kDa scaffolding protein that plays an important role in the regulation of cell adhesion, migration, proliferation, differentiation, polarization and cytoskeletal remodeling. IQGAP1 is ubiquitously expressed in human organs and is highly… read more here.
Keywords: iqgap1; site specific; specific expression; iqgap1 human ... See more keywords
IQGAP1 scaffolding links Phosphoinositide Kinases to Cytoskeletal Reorganization.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.01.018
Abstract: IQGAP1 is a multi-domain scaffold protein that coordinates the direction and impact of multiple signaling pathways by scaffolding its various binding partners. However, the spatial and temporal resolution of IQGAP1 scaffolding remains unclear. Here, we… read more here.
Keywords: iqgap1 scaffolding; iqgap1; cytoskeletal reorganization; cytoskeletal changes ... See more keywords
SUMOylation of IQGAP1 promotes the development of colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.046
Abstract: IQGAP1 is a conserved multifunctional protein implicated in tumorigenesis. An aberrant expression of IQGAP1 widely exists in many cancers, but the SUMOylation modification of IQGAP1 in carcinogenesis is unknown by now. Here we first time… read more here.
Keywords: sumoylation; iqgap1; colorectal cancer; crc ... See more keywords
IQGAP1 and RNA Splicing in the Context of Head and Neck via Phosphoproteomics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00309
Abstract: IQGAP1 (IQ motif-containing GTPase-activating protein 1) scaffolds several signaling pathways in mammalian cells that are implicated in carcinogenesis, including the RAS and PI3K pathways that involve multiple protein kinases. IQGAP1 has been shown to promote… read more here.
Keywords: head neck; rna splicing; iqgap1 rna; iqgap1 ... See more keywords
IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-0970-z
Abstract: Background Hepatitis B virus (HBV) has a crucial role in the progression of hepatocellular carcinoma (HCC). Tumour cells must develop anoikis resistance in order to survive before metastasis. This study aimed to investigate the mechanism… read more here.
Keywords: iqgap1; hbv; metastasis; anoikis resistance ... See more keywords
Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00190h
Abstract: The ability to modulate angiogenesis by chemical tools has several important applications in different scientific fields. With the perspective of finding novel proangiogenic molecules, we searched peptide sequences with a chemical profile similar to that… read more here.
Keywords: iqgap1; peptide; vegf mimetic; iqgap1 protein ... See more keywords
IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Oncotarget"
DOI: 10.18632/oncotarget.27623
Abstract: Triple negative breast cancer (TNBC) is a heterogenous and lethal disease that lacks diagnostic markers and therapeutic targets; as such common targets are highly sought after. IQGAP1 is a signaling scaffold implicated in TNBC, but… read more here.
Keywords: iqgap1; negative breast; breast cancer; distinct variants ... See more keywords
IQGAP1 plays an important role in the tumorigenesis and invasion of papillary thyroid cancer
Sign Up to like & getrecommendations! Published in 2018 at "Translational cancer research"
DOI: 10.21037/23594
Abstract: Background: Numerous studies have indicated that IQGAP1 plays an important role in human cancers. The present study aimed to investigate the IQGAP1 expression pattern in papillary thyroid cancer (PTC) and its relationship with tumor proliferation,… read more here.
Keywords: iqgap1; invasion; important role; expression ... See more keywords