IQGAP3 signalling mediates intratumoral functional heterogeneity to enhance malignant growth
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DOI: 10.1136/gutjnl-2023-330390
Abstract: Background The elevation of IQGAP3 expression in diverse cancers indicates a key role for IQGAP3 in carcinogenesis. Although IQGAP3 was established as a proliferating stomach stem cell factor and a regulator of the RAS-ERK pathway,… read more here.
Keywords: malignant growth; iqgap3; enhance malignant; functional heterogeneity ... See more keywords
Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer
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DOI: 10.1155/2022/4822964
Abstract: Background IQGAP3 has important function in cancer progression and has become a potential therapeutic target as a transmembrane protein. But its role in tumor immunity and pan-cancer was not systematically investigated. This study evaluated the… read more here.
Keywords: iqgap3; multiomics analysis; pan cancer; expression ... See more keywords
Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma
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DOI: 10.1186/s12967-017-1275-8
Abstract: BackgroundHepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide owing to its high rates of metastasis and recurrence. The oncogene IQ motif-containing GTPase activating protein 3 (IQGAP3) is ubiquitously overexpressed in several human… read more here.
Keywords: mesenchymal transition; hcc; metastasis; epithelial mesenchymal ... See more keywords