Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103345
Abstract: Background near-infrared photoimmunotherapy (NIR-PIT) is a cancer treatment that uses antibody-photoabsorber (IRDye700DX, IR700) conjugates (APCs) which bind to target cells and are photoactivated by NIR light inducing rapid necrotic cell death. NIR-PIT targeting human epidermal… read more here.
Keywords: pit; nir pit; hegfr; cd25 ... See more keywords
Phototheranostics of Splenic Myeloid-Derived Suppressor Cells and Its Impact on Spleen Metabolism in Tumor-Bearing Mice
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DOI: 10.3390/cancers14153578
Abstract: Simple Summary Myeloid-derived suppressor cells (MDSCs) create an immune suppressive tumor microenvironment making them an important target in cancer. Here we demonstrated, in proof-of-principle studies, the ability of near-infrared photoimmunotherapy (NIR-PIT) to visualize and selectively… read more here.
Keywords: ir700; tumor bearing; nir pit; mice ... See more keywords
A low molecular weight multifunctional theranostic molecule for the treatment of prostate cancer
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DOI: 10.7150/thno.68715
Abstract: Rationale: Although surgery and radiation therapy in patients with low risk prostate cancer appear appropriate and effective, those with high-risk localized disease almost always become hormone refractory and then rapidly progress. A new treatment strategy… read more here.
Keywords: prostate cancer; ir700; molecule; psma ... See more keywords