Rheumatic immune-related adverse events associated with cancer immunotherapy: A nationwide multi-center cohort.
Sign Up to like & getrecommendations! Published in 2020 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2020.102595
Abstract: OBJECTIVE Although immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, their use is associated with immune toxicities referred to as immune-related adverse events (irAE). Here we describe the clinical presentation and management of rheumatic immune-related… read more here.
Keywords: adverse events; immune related; treatment; cohort ... See more keywords
Association between immune-related adverse event timing and treatment outcomes
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DOI: 10.1080/2162402x.2021.2017162
Abstract: ABSTRACT The timing of immune-related adverse events (irAE) associated with immune checkpoint inhibitors (ICI) is highly variable. Although the development of irAE has been associated with ICI clinical benefit, how irAE timing influences this association… read more here.
Keywords: utsw cohort; immune related; related adverse; cohort ... See more keywords
The therapeutic effect and immune-related adverse event of nivolmab in Anjo Kosei Hospital
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DOI: 10.1093/annonc/mdz343.079
Abstract: Abstract Background Nivolmab is approved as a novel immunocheckpoint inhibitor and peculiar immune-related adverse events (irAE) including interstitial lung disease (ILD), endocrinological disorder, and immunological colitis are reported. The rapid diagnosis and treatment are indispensable… read more here.
Keywords: immune related; therapeutic effect; effect; related adverse ... See more keywords
191 Association of immune related adverse events with the efficacy of immune checkpoint inhibitors in metastatic renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0191
Abstract: Background Immune checkpoint inhibitors (ICI) are first-line therapy for tumors including metastatic renal cell carcinoma (mRCC). Use of ICI is complicated by diverse immune-related adverse events (irAEs), which can add significant morbidity but are also… read more here.
Keywords: adverse events; immune related; related adverse; irae ... See more keywords
Lower baseline autoantibody levels are associated with immune-related adverse events from immune checkpoint inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004008
Abstract: Introduction Immune checkpoint inhibitors (ICI) are a novel cancer therapeutic that have been successful in treating advanced malignancies; however, they also cause immune-related adverse events (irAE). Given that some irAE are clinically similar to traditional… read more here.
Keywords: baseline; immune checkpoint; autoantibody; immune related ... See more keywords
Early Use of High-Dose Glucocorticoid for the Management of irAE Is Associated with Poorer Survival in Patients with Advanced Melanoma Treated with Anti–PD-1 Monotherapy
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DOI: 10.1158/1078-0432.ccr-21-1283
Abstract: Purpose: Programmed cell death receptor-1 (PD-1) inhibitors are frontline therapy in advanced melanoma. Severe immune-related adverse effects (irAEs) often require immunosuppressive treatment with glucocorticoids (GCCs), but GCC use and its correlation with patient survival outcomes… read more here.
Keywords: gcc use; post irae; anti monotherapy; irae ... See more keywords
Assessment of hospitalization rates for immune-related adverse events with immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155220968909
Abstract: Introduction Immune checkpoint inhibitors (ICIs) have become the standard of care in many cancer types. As the number of patients receiving ICIs for various cancers continues to expand, patients and practitioners should be aware of… read more here.
Keywords: immune checkpoint; hospitalization; checkpoint inhibitors; immune related ... See more keywords
Histological diagnosis of immune checkpoint inhibitor induced acute renal injury in patients with metastatic melanoma: a retrospective case series report
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DOI: 10.1186/s12882-020-02044-9
Abstract: Background Immune checkpoint inhibitors (ICI) have become the standard of care in many oncological conditions but are associated with a spectrum of renal immune-related adverse events (IrAEs). We aimed to describe the spectrum, histology, management… read more here.
Keywords: immune checkpoint; renal irae; patients metastatic; metastatic melanoma ... See more keywords
Optimization of immune-related adverse event management in a thoracic oncology clinic.
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DOI: 10.1200/jco.2018.36.30_suppl.261
Abstract: 261 Background: Improved awareness and management of immune checkpoint inhibitor (ICI) related adverse events (IRAEs) is a mandate for best practice given widespread use of ICIs in clinic. IRAE grading is standardized by the Common… read more here.
Keywords: oncology clinic; thoracic oncology; management; iraes ... See more keywords
Predictable early onset high-dose-glucocorticoid-associated-irAE and its predictive role in anti-PD-1 monotherapy treated advanced melanoma patients.
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DOI: 10.1200/jco.2019.37.15_suppl.9544
Abstract: 9544 Background: Though uncommon, a subgroup of patients with melanoma develop early-onset severe immune-related adverse effects (irAEs) that require immunosuppressive treatment with high-dose glucocorticoids (HD-GCCs). We aimed to examine the impact of early onset HD-GCC-associated-irAE… read more here.
Keywords: early onset; hga irae; anti monotherapy; irae ... See more keywords
Immune-related adverse event (irAE) education, self-efficacy, and potential irAE experiences in patients treated with immunotherapy for non-small cell lung cancer (NSCLC).
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DOI: 10.1200/jco.2019.37.8_suppl.76
Abstract: 76 Background: Immunotherapy presents new challenges for effective patient engagement to ensure that irAEs are reported and treated appropriately. This study directly assesses how NSCLC patients in an online community perceived their irAE education and… read more here.
Keywords: irae education; irae; potential irae; iraes ... See more keywords