Pharmacological inhibition of IRAK1 attenuates colitis‐induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial–mesenchymal transition
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DOI: 10.1002/jbt.22838
Abstract: Colorectal cancer (CRC) is the third most common type of cancer. Here, we studied the inhibitory effect of IRAK1 and IRAK4 as a preventive strategy using a colitis‐induced tumorigenesis mouse model. CRC clinical data were… read more here.
Keywords: induced tumorigenesis; irak1 inhibitor; colitis induced; epithelial mesenchymal ... See more keywords
Inhibition of IRAK1/4 enhances the antitumor effect of lenvatinib in anaplastic thyroid cancer cells.
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DOI: 10.1111/cas.15095
Abstract: Anaplastic thyroid cancer (ATC) is an extremely aggressive tumor associated with poor prognosis due to a lack of efficient therapies. In Japan, lenvatinib is the only drug approved for patients with ATC; however, its efficacy… read more here.
Keywords: lenvatinib; irak1 inhibitor; inhibitor; anaplastic thyroid ... See more keywords
Cooperation of IRAK1/4 inhibitor and ABT-737 in nanoparticles for synergistic therapy of T cell acute lymphoblastic leukemia [Corrigendum]
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DOI: 10.2147/ijn.s162136
Abstract: [This corrects the article on p. 8025 in vol. 12, PMID: 29184402.]. read more here.
Keywords: irak1 inhibitor; nanoparticles synergistic; cooperation irak1; inhibitor abt ... See more keywords