The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Journal"
DOI: 10.1042/bcj20170097
Abstract: We have developed the first assays that measure the protein kinase activities of interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4 reliably in human cell extracts, by employing Pellino1 as a substrate in conjunction with specific… read more here.
Keywords: receptor; irak1 irak4; activation irak1; irak4 ... See more keywords
IRAK1 and IRAK4 signaling proteins are dispensable in the response of human neutrophils to Mycobacterium tuberculosis infection.
Sign Up to like & getrecommendations! Published in 2019 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnz226
Abstract: The involvement of neutrophils in the host response to Mycobacterium tuberculosis (Mtb) infection is not as well recognized as the involvement of macrophages and dendritic cells. Thus, this study gives more insight on the impact… read more here.
Keywords: response; irak1 irak4; infection; signaling proteins ... See more keywords
Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022018718
Abstract: Dysregulation of innate immune signaling is a hallmark of hematologic malignancies. Recent therapeutic efforts to subvert aberrant innate immune signaling in MDS and AML have focused on the kinase IRAK4. IRAK4 inhibitors have achieved promising,… read more here.
Keywords: mds aml; myd88 independent; irak4; irak1 irak4 ... See more keywords