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   Articles with "irak4" as a keyword



IRAK4 exacerbates traumatic brain injury via activation of TAK1 signaling pathway

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recommendations! Published in 2022 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2022.114007

Abstract: Although multiple signaling pathways contributing to the pathophysiological process have been investigated, treatments for traumatic brain injury (TBI) against present targets have not acquired significant clinical progress. Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important… read more here.

Keywords: injury; tak1 signaling; signaling pathway; activation tak1 ... See more keywords

Acanthoic acid protectsagainst ethanol-induced liver injury: Possible role of AMPK activation and IRAK4 inhibition.

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recommendations! Published in 2017 at "Toxicology letters"

DOI: 10.1016/j.toxlet.2017.09.020

Abstract: The aim of this study was to investigate the effects of acanthoic acid (AA) on the regulation of inflammatory response, lipid accumulation, and fibrosis via AMPK- IRAK4 signaling against chronic alcohol consumption in mice. Ethanol-induced… read more here.

Keywords: acanthoic acid; ampk; ethanol; liver injury ... See more keywords

Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00181

Abstract: Interleukin-1 receptor-associated kinase 4 (IRAK4) is a promising therapeutic target in inflammation-related diseases. However, the inhibition of IRAK4 kinase activity may lead to moderate anti-inflammatory efficacy owing to the dual role of IRAK4 as an… read more here.

Keywords: interleukin receptor; associated kinase; receptor associated; irak4 ... See more keywords

Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia

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recommendations! Published in 2019 at "Leukemia"

DOI: 10.1038/s41375-019-0507-8

Abstract: Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses. Recruitment and subsequent activation of IRAK4 upon TLR stimulation is mediated by the myeloid differentiation primary… read more here.

Keywords: cll; lymphocytic leukemia; chronic lymphocytic; leukemia ... See more keywords

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

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recommendations! Published in 2025 at "Leukemia"

DOI: 10.1038/s41375-025-02695-3

Abstract: IRAK4 is a therapeutic target in myeloid malignancies, but current IRAK4 inhibitors show only modest clinical efficacy in acute myeloid leukemia, highlighting the need for combination strategies. To identify drugs with synergistic potential alongside IRAK4… read more here.

Keywords: leukemic cells; aml; irak4; efficacy ... See more keywords

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

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recommendations! Published in 2017 at "Biochemical Journal"

DOI: 10.1042/bcj20170097

Abstract: We have developed the first assays that measure the protein kinase activities of interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4 reliably in human cell extracts, by employing Pellino1 as a substrate in conjunction with specific… read more here.

Keywords: receptor; irak1 irak4; activation irak1; irak4 ... See more keywords
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IRAK4 signaling drives resistance to checkpoint immunotherapy in pancreatic ductal adenocarcinoma.

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recommendations! Published in 2022 at "Gastroenterology"

DOI: 10.1053/j.gastro.2022.02.035

Abstract: BACKGROUND AND AIMS Checkpoint immunotherapy is largely ineffective in pancreatic ductal adenocarcinoma (PDAC). The innate immune NF-κB pathway promotes PDAC cell survival, stromal fibrosis and is driven by IRAK4, but its impact on tumor immunity… read more here.

Keywords: pancreatic ductal; irak4; cell; checkpoint immunotherapy ... See more keywords

Abstract 127: Efficacy of novel IRAK4 inhibitor CA4948 in AML and MDS

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-127

Abstract: Myelodysplastic syndrome (MDS) & Acute Myeloid Leukemia (AML) are hematologic malignancies that arise from a population of aberrant hematopoietic stem cells (HSCs). Overactivated innate immune signaling pathways such as IRAK1, TRAF6, IL1RAP, S100A9 and IL8… read more here.

Keywords: inhibitor; mds aml; efficacy; mds ... See more keywords

Abstract LB-083: Targeting IRAK4 disrupts inflammatory pathways and tumor microenvironment in chronic lymphocytic leukemia regardless MYD88 mutational status

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recommendations! Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-lb-083

Abstract: BACKGROUND & AIM. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and the innate immune response. Recruitment of IRAK4 to these receptors and its subsequent activation is facilitated… read more here.

Keywords: cll; mutational status; myd88 mutational; chronic lymphocytic ... See more keywords
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IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colon cancer.

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recommendations! Published in 2019 at "JCI insight"

DOI: 10.1172/jci.insight.130867

Abstract: Aberrant activation of the NF-κB transcription factors underlies chemoresistance in various cancer types including colorectal cancer (CRC). Targeting the activating mechanisms, particularly with inhibitors to the upstream IκB kinase (IKK) complex, is a promising strategy… read more here.

Keywords: irak4 mediates; colitis induced; crc; cancer ... See more keywords

Targeting of Various Inflammatory Circuits Does Not Ameliorate Ineffective Hematopoiesis: Results of the Lucas and Canfire Studies Investigating IRAK4 or IL-1β Blockade to Target Anemia in Lower-Risk MDS

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-199032

Abstract: Background Myelodysplastic neoplasms (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are hematologic malignancies characterized by dysfunctional hematopoiesis. These disorders frequently exhibit upregulation of inflammatory pathways, particularly those involving interleukin-1β (IL-1β) and interleukin-1 receptor-associated kinase 4 (IRAK4) within… read more here.

Keywords: treatment; hematopoiesis; lucas canfire; irak4 ... See more keywords