IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colon cancer.
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DOI: 10.1172/jci.insight.130867
Abstract: Aberrant activation of the NF-κB transcription factors underlies chemoresistance in various cancer types including colorectal cancer (CRC). Targeting the activating mechanisms, particularly with inhibitors to the upstream IκB kinase (IKK) complex, is a promising strategy… read more here.
Keywords: irak4 mediates; colitis induced; crc; cancer ... See more keywords