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Published in 2020 at "ChemistryOpen"
DOI: 10.1002/open.201900344
Abstract: Abstract Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats. The majority…
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Keywords:
oxindole dihydroquinazolinones;
irap inhibitors;
evaluation proposed;
irap ... See more keywords
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2
Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732668
Abstract: Study Objective: Understand the response to acute water load in mice lacking the insulin-regulated aminopeptidase (IRAP). Hypothesis: IRAP degrades vasopressin in vivo, therefore, mice lacking IRAP would have impaired ability to dilute urine and to…
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Keywords:
water;
irap;
physiology;
acute water ... See more keywords
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Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.585713
Abstract: Dendritic cells (DCs) contribute to the immune surveillance by sampling their environment through phagocytosis and endocytosis. We have previously reported that, rapidly following uptake of extracellular antigen into phagosomes or endosomes in DCs, a specialized…
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Keywords:
phagosome maturation;
cross presentation;
irap;
dendritic cells ... See more keywords
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1
Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1002375
Abstract: The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum…
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Keywords:
system;
angiotensin;
antigen processing;
irap ... See more keywords
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Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.585930
Abstract: The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total…
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Keywords:
inspiration;
irap inhibitors;
aminopeptidase family;
irap ... See more keywords
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Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.590855
Abstract: It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related…
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Keywords:
small peptidemimetics;
regulated aminopeptidase;
irap;
insulin regulated ... See more keywords
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1
Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44100340
Abstract: Angiotensin IV (Ang IV), a metabolite of Angiotensin II, is a bioactive hexapeptide that inhibits the insulin-regulated aminopeptidase (IRAP). This transmembrane zinc metallopeptidase with many biological functions has in recent years emerged as a new…
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Keywords:
hydrogen peroxide;
cell;
irap;
ha08 ... See more keywords