Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors
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DOI: 10.1002/open.201900344
Abstract: Abstract Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats. The majority… read more here.
Keywords: oxindole dihydroquinazolinones; irap inhibitors; evaluation proposed; irap ... See more keywords
IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
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DOI: 10.3389/fphar.2020.585930
Abstract: The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total… read more here.
Keywords: inspiration; irap inhibitors; aminopeptidase family; irap ... See more keywords