Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.04.023
Abstract: Increasing evidence suggests that endoplasmic reticulum (ER) stress activates several pro-inflammatory signaling pathways in many diseases, including acute lung injury (ALI). We have reported that blocking triggering receptor expressed on myeloid cells 1 (TREM-1) protects… read more here.
Keywords: ire xbp; stress; pro inflammatory; trem ... See more keywords
Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2017009068
Abstract: Hematopoietic stem cell transplantation (HCT) is a curative procedure for hematological malignancies, but chronic graft-versus-host disease (cGVHD) remains a major complication after allogeneic HCT. Because donor B cells are essential for cGVHD development and B… read more here.
Keywords: xbp pathway; ire xbp; cell; cgvhd ... See more keywords