Human cDC1 display constitutive activation of the UPR Sensor IRE1.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149774
Abstract: The intracellular mechanisms safeguarding dendritic cell (DC) function are of biomedical interest in several immune-related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation of the unfolded protein response… read more here.
Keywords: biology; ire1; ire1 rnase; upr sensor ... See more keywords
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.03.018
Abstract: In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)-IRE1α-endonucleolytically degrades ER-localized mRNAs to promote apoptosis. Here we find that the ABL family of tyrosine kinases rheostatically enhances IRE1α's enzymatic activities, thereby… read more here.
Keywords: ire1 rnase; abl ire1; targeting abl; ire1 signaling ... See more keywords
Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00802
Abstract: Inositol-requiring enzyme 1α (IRE1α) is one of three endoplasmic reticulum stress sensors. Upon activation of its kinase domain, IRE1α splices the mRNA substrate XBP1, which activates the unfolded protein response. IRE1α has emerged as a… read more here.
Keywords: inhibitor; kinase; based kira6; kinase photoaffinity ... See more keywords
Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00344
Abstract: Amino-quinazoline BRaf kinase inhibitor 2 was identified from a library screen as a modest inhibitor of the unfolded protein response (UPR) regulating potential anticancer target IRE1α. A combination of crystallographic and conformational considerations were used… read more here.
Keywords: amino; braf activity; braf; identification braf ... See more keywords
PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11019-w
Abstract: Unfolded protein response (UPR) is an adaptive mechanism that aims at restoring ER homeostasis under severe environmental stress. Malignant cells are resistant to environmental stress, which is largely due to an activated UPR. However, the… read more here.
Keywords: ire1; environmental stress; stress; prkcsh contributes ... See more keywords
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19974-5
Abstract: Inositol-Requiring Enzyme 1 (IRE1) is an essential component of the Unfolded Protein Response. IRE1 spans the endoplasmic reticulum membrane, comprising a sensory lumenal domain, and tandem kinase and endoribonuclease (RNase) cytoplasmic domains. Excess unfolded proteins… read more here.
Keywords: kinase front; kinase; atp competitive; rnase ... See more keywords
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-27597-7
Abstract: Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates the transcription factor XBP1s by… read more here.
Keywords: reticulum stress; ire1; decay; endoplasmic reticulum ... See more keywords
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
Sign Up to like & getrecommendations! Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0141-0
Abstract: Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer IRE1α.… read more here.
Keywords: cytoskeleton; cell migration; filamin; ire1 ... See more keywords
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1906999116
Abstract: Significance Multiple myeloma (MM) is a lethal malignancy arising from plasma cells. MM cells experience endoplasmic reticulum (ER) stress due to immunoglobulin hyperproduction. The ER-resident sensor IRE1α mitigates ER stress by expanding protein-folding and secretion… read more here.
Keywords: xbp1s; kinase; multiple myeloma; ire1 kinase ... See more keywords
Kai-Xin-San improves cognitive impairment via Wnt/β-catenin and IRE1/XBP1s signalings in APP/PS1 mice.
Sign Up to like & getrecommendations! Published in 2023 at "Rejuvenation research"
DOI: 10.1089/rej.2022.0063
Abstract: Alzheimer's disease (AD) is the most common type of dementia with an insidious onset and slow progression. Kai-Xin-San (KXS) has been reported to be effective in improving cognitive impairment in AD. However, the mechanism is… read more here.
Keywords: app ps1; xbp1s; ire1; mice ... See more keywords
IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao4617
Abstract: A high-fat diet causes liver disease by suppressing IRE1α-regulated microRNA biogenesis. Fat, microRNAs, and liver disease Obesity and high-fat diets are linked to fatty liver disease and repression of the cell stress protein IRE1α. By… read more here.
Keywords: fat diet; hepatic steatosis; liver; high fat ... See more keywords